126065-71-2Relevant academic research and scientific papers
REGIOSELECTIVE ACYLATIVE CLEAVAGE OF CYCLIC FORMAL OF CHLORAMPHENICOL
Hazra, B. G.,Pore, V. S.,Maybhate, S. P.,Natekar, M. V.,Rao, A. S.
, p. 1763 - 1770 (2007/10/02)
The amide 6 has been synthesised by reacting the amine 3 with dichloroketene in situ.This amide 6 on nitration gave formal 7, which when reacted with acetic anhydride and p-toluene sulfonic acid underwent regioselective cleavage of the dioxane ring to furnish the hemiacetal 11.This on treatment with methanol-water-ammonia yielded chloramphenicol 2.
