78021-92-8

Usage

Class

Amines

Derivative of

Dioxane

Usage

Organic synthesis and pharmaceutical research

Application

Building block for various compounds

Studies

Potential use in the development of new drugs and therapeutic agents

Investigation

Biological activities and potential pharmacological properties

Field of relevance

Medicinal chemistry and drug discovery

Unique feature

Valuable component due to its chemical structure and properties

Upstream product

• 2425-28-7 2-Bromo-1-phenylethanol 
• 103-64-0 bromostyrene 
• 100-42-5 styrene 
• 77940-37-5 5-bromo-4-phenyl-[1,3]dioxane 
• 140-10-3 (E)-3-phenylacrylic acid 
• 2231-67-6 (+/-)-trans-4-phenyl-[1,3]dioxane-5-carboxylic acid 
• 103502-03-0 (+/-)-trans-4-phenyl-[1,3]dioxane-5-carboxylic acid amide 

Downstream Products

• 94908-60-8 (+/-)-N-(trans-4-phenyl-[1,3]dioxan-5-yl)-benzamide 
• 92576-55-1 cis (+/-)-4-phenyl-5-dichloroacetamido-1,3-dioxane 
• 92695-77-7 cis (+/-)-4-p-nitrophenyl-5-dichloroacetamido-1,3-dioxane 
• 126482-97-1 2,2-Dichloro-N-[(4S,5S)-4-(2-nitro-phenyl)-[1,3]dioxan-5-yl]-acetamide 
• 126065-71-2 2,2-Dichloro-N-[(4S,5S)-4-(3-nitro-phenyl)-[1,3]dioxan-5-yl]-acetamide 
• 126065-73-4 Acetic acid (2-dichloromethyl-4,5-dihydro-oxazol-4-yl)-(4-nitro-phenyl)-methoxymethyl ester 
• 56-75-7 threo (+/-)-2,2-dichloro-N-<2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl> acetamide 
• 126065-72-3 threo (+/-)-1-(acetoxymethoxy)-3-acetoxy-2-dichloroacetamido-1-p-nitrophenylpropane 
• 3306-06-7 (+/-)-threo-2-amino-1-phenyl-1,3-propanediol 
• 2271-58-1 (1RS,2RS)-2-amino-1-(4-nitro-phenyl)-propane-1,3-diol; hydrochloride 
• 119-62-0 (+/-)-threo-1-(4-nitro-phenyl)-2-amino-1,3-propanediol 
• 56-75-7 chloramphenicol 
• 10318-17-9 (1R,2R)-3-(acetyloxy)-2-[(dichloroacetyl)amino]-1-(4-nitrophenyl)propyl acetate 
• 98045-53-5 cis (-)-(4R)-p-nitrophenyl-(5R)-dichloroacetamido-1,3-dioxane 

Relevant academic research and scientific papers

Cis-platinum-diamine complexes and antitumorous compositions containing them, and process for their preparation

The present invention relates to novel cis-platinumdiamine complexes represented by the general formula (I) and the process of preparation thereof. The definitions of the substituents in the above-mentioned formula are the same as defined in the specification. The present invention also provides antitumorous compositions containing one or more of the above-said complexes as active ingredients. STR1

STEREOSELECTIVE SYNTHESIS OF (+/-)-threo-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL

Addition of hypobromic acid to styrene afforded styrene bromohydrin (I) which was dehydrated to ω-bromostyrene (II).Prince reaction of II with aqueous formaldehyde gave 5-bromo-4-phenyl-1,3-dioxane (III).The bromine atom in III was replaced with amino group by treatment with methanolic ammonia at 150 deg C and 6 - 8 MPa and the obtained threo-5-amino-4-phenyl-1,3-dioxane (IVa) was hydrolyzed to give (+/-)-threo-2-amino-1-phenyl-1,3-propanediol (V).Suitably chosen method of nitration converted the free base IVa or its N-acetyl derivative IVb into 5-amino-4-(4-nitrophe nyl)-1,3-dioxane (VIa) or its N-acetyl derivative VIb which without isolation were hydrolyzed to threo-2-amino-1-(4-nitrophenyl)-1,3-propanediol (VII), isolated as hydrochloride.The liberated base was resolved into enantiomers and dichloroacetylated in the known manner to give D-(-)-threo-2-dichloroacetylamino-1-(4-nitrophenyl)-1,3-propanediol (chloramphenicol).