1260667-65-9

Basic information

• Product Name: 5-chloro-4-iodopyridin-2-amine
• Synonyms: 5-chloro-4-iodopyridin-2-amine
• CAS NO: 1260667-65-9
• Molecular Formula: C₅H₄ClIN₂
• Molecular Weight: 254.45613
• Mol File: 1260667-65-9.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 5-chloro-4-iodopyridin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-4-iodopyridin-2-amine(1260667-65-9)
• EPA Substance Registry System: 5-chloro-4-iodopyridin-2-amine(1260667-65-9)

Safety Data

• Hazardous Substances Data: 1260667-65-9(Hazardous Substances Data)

Upstream product

• 659731-48-3 5-chloro-2-fluoro-4-iodopyridine 

Downstream Products

• 2057509-72-3 (1S,3R)-3-acetamido-N-(5-chloro-4-(5,5-dimethyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)pyridin-2-yl)cyclohexane-1-carboxamide 
• 2057509-72-3 (1R,3S)-3-acetamido-N-(5-chloro-4-(5,5-dimethyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)pyridin-2-yl)cyclohexanecarboxamide 
• 2057509-72-3 cis-3-acetamido-N-(5-chloro-4-(5,5-dimethyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)pyridin-2-yl)cyclohexanecarboxamide 
• 1339129-46-2 5-chloro-3-(2-methoxyphenyl)pyridin-2-amine 
• 1270077-79-6 (R)-3-[5'-chloro-6-(cyclohexylmethylamino)-[2,4,]bipyridinyl-2'-ylcarbamoyl]piperidine-1-carboxylic acid tert-butyl ester 
• 1269815-52-2 (R)-tert-butyl 3-(5-chloro-4-phenylpyridin-2-ylcarbamoyl)piperidine-1-carboxylate trifluoroacetate 

Relevant articles and documents

From Milligram to Kilogram Manufacture of AZD4573: Making It Possible by Application of Enzyme-, Iridium-, and Palladium-Catalyzed Key Transformations

With the first generation medicinal chemistry synthesis as a starting point, we describe herein process development of AZD4573, an oncology drug candidate. In addition to improved yields and removal of chromatographic steps, we have addressed other factors such as availability of starting materials as well as safety of the chemistry involved. With several steps involving volatile, reactive, and non-UV active materials, reaction optimization was facilitated by implementing off-line 1H NMR analysis of crude mixtures. Key transformations targeted for process development included a Wolff-Kishner reduction, an iridium-catalyzed borylation, and enzymatic resolution of a racemic amino-ester.

Preparation method and application of N-(pyrimidine-2-yl) coumarin-7-amine derivative as protein kinase inhibitor

The invention discloses a cyclin-dependent kinase inhibitor. The cyclin-dependent kinase inhibitor comprises an N-(pyrimidine-2-yl) coumarin-7-amine derivative shown as a general formula (I). In-vitropharmacodynamic tests prove that the compound has a high-selectivity inhibition effect on CDK9 kinase, and can be applied to reducing or inhibiting the activity of CDK9 kinase in cells. The inventionalso discloses a preparation method of the inhibitor and application of the inhibitor in drugs for CDK family kinase mediated diseases, especially hyperproliferative diseases, virus-induced infectious diseases and cardiovascular diseases.

N-ACYL PYRIDINE BIARYL COMPOUNDS AND THEIR USES

The present invention provides a compound of general formula:wherein Z2-Z6 include one or two nitrogen atoms as described herein, including pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof. These compounds inhibit the activity of CDK9 and are thus useful as pharmaceuticals. Also provided are methods of treating a disease or condition mediated by CDK9 using the compounds of Formula I and isomers thereof, and pharmaceutical compositions comprising such compounds.