126079-17-2Relevant academic research and scientific papers
A short synthesis of polysubstituted pyrrolidines via α-(Alkylidene- amino)nitriles
Meyer, Nino,Opatz, Till
, p. 787 - 790 (2004)
α-(Alkylideneamino)nitriles can be deprotonated under mild conditions. Their conjugated anions react with enones in a 1,4-addition to yield δ-keto-α-(alkylideneamino)nitriles which in turn can be reduced to form pyrrolidines in a one-pot reaction sequence
One-pot synthesis of polysubstituted pyrrolidines from aminonitriles
Meyer, Nino,Werner, Frank,Opatz, Till
, p. 945 - 956 (2007/10/03)
α-Aminonitriles with a mono- or unsubstituted amino group as well as α-(alkylideneamino)nitriles can be employed as easily accessible α-aminocarbanion equivalents. Their α-deprotonation yields stabilized carbanions, which undergo smooth 1,4-addition to α,β- unsaturated carbonyl compounds. The resulting δ-keto-α-aminonitriles can be reductively cyclized to form polysubstituted pyrrolidines. Georg Thieme Verlag Stuttgart.
