151-63-3

Usage

Chemical Properties

white to yellow-beige crystalline powder and

Purification Methods

Recrystallise the hydrogensulfate (1:1) from EtOH/Et2O (hygroscopic leaflets). The Sulfate (2:1) [5466-22-8] crystallises as flat prisms from H2O/EtOH with m 166o(dec). [Stephen J Chem Soc 871 1931, Anslow & King J Chem Soc 2465 1929, Beilstein 4 III 1120.]

InChI:InChI=1/C2H4N2.H2O4S/c3-1-2-4;1-5(2,3)4/h1,3H2;(H2,1,2,3,4)

Upstream product

• 109-82-0 methyleneaminoacetonitrile 
• 64-17-5 ethanol 

Downstream Products

• 22978-17-2 N-Cyanomethyl-4-methoxy-3-nitro-benzamide 
• 22978-16-1 N-Cyanomethyl-3,5-dimethyl-4-nitro-benzamide 
• 5692-27-3 2-benzamido-ethanenitrile 
• 3589-41-1 phenylmethyl cyanomethylcarbamate 
• 22978-68-3 N-(2-Chloro-4-nitrobenzoyl)aminoacetonitrile 
• 13297-44-4 o-Nitrobenzamido-acetonitril 
• 22978-08-1 4-Chloro-N-cyanomethyl-3-nitro-benzamide 
• 5018-27-9 N-formylamino-acetonitrile 
• 22978-13-8 N-Cyanomethyl-3,5-dinitro-benzamide 
• 87612-96-2 6-cyano-1,3,4,7-tetraphenylthieno<3,4-c>pyridine 
• 80379-49-3 6-cyano-2-methyl-1,3,4,7-tetraphenylpyrrolo<3,4-c>pyridine 
• 4764-17-4 3,4-methylenedioxyamphetamine 
• 20855-76-9 <<(benzyloxycarbonyl)glycyl>amino>acetonitrile 
• 76109-69-8 1-(p-carboxamidophenyl)-3-(cyanomethyl)triazene 

Relevant academic research and scientific papers

Synthesis of [3-13C]-, [4-13C]- and [11- 13C]-porphobilinogen

[4-13C]-porphobilinogen 1a, [3-13C]-porphobilinogen 1b and [11-13C]-porphobilinogen 1c are prepared from [1- 13C]-3-(tetrahydropyran-20-yloxy)-propionaldehyde 2a, methyl [4- 13C]-4-nitrobutyrate 3b and [1-13C]-isocyanoacetonitrile 5c, respectively. The building blocks 2, 3 and 5 can be prepared efficiently in any isotopomeric form. Via base-catalyzed condensation of these building blocks porphobilinogen can be enriched with 13C and 15N stable isotopes at any position and combination of positions. Copyright

The Ion-exchange Chromatography of Imino Derivatives of Glycine

The resolution of the six imino derivatives of glycine (Gly) by ion-exchange chromatography is described.The imino compounds included iminodiacetonitrile (1), iminodiacetamide (2), iminodiacetic acid (3), α-(cyanomethylamino)acetamide (4), α-(cyanomethylamino)acetic acid (5), and α-(carbamoylmethylamino)acetic acid (6).A mixture of 1-6 was chromatographed along with Gly, glycinamide, aminoacetonitrile, and NH3 with an automatic amino acid analyzer using Aminex A-4 resin column (0.25φ x 50 cm) and sodium citrate buffers.When the initial buffer of pH 3.25 was changed to pH 6.50 15 min after beginning the analysis, these ten components were completely resolved.The analysis was completed in about 4.5 h.The stability of 1, 4, and 5 in aqueous media at room temperature was also studied.