1260903-17-0

Basic information

• Product Name: 7-Fluoro-imidazo[1,2-a]pyridine
• Synonyms: 7-Fluoro-imidazo[1,2-a]pyridine
• CAS NO: 1260903-17-0
• Molecular Formula: C7H5FN2
• Molecular Weight: 136.1264032
• Mol File: 1260903-17-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.27±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 5.74±0.50(Predicted)
• CAS DataBase Reference: 7-Fluoro-imidazo[1,2-a]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Fluoro-imidazo[1,2-a]pyridine(1260903-17-0)
• EPA Substance Registry System: 7-Fluoro-imidazo[1,2-a]pyridine(1260903-17-0)

Safety Data

• Hazardous Substances Data: 1260903-17-0(Hazardous Substances Data)

Usage

General Description

7-Fluoro-imidazo[1,2-a]pyridine is a chemical compound with the molecular formula C8H6FN3. It is a heterocyclic organic compound that contains a fluorine atom and is derived from pyridine. It is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals due to its ability to act as a versatile precursor in chemical reactions. The compound has been studied for its potential biological activities, including its use as an antibacterial and antifungal agent. Its structure and properties make it a valuable tool for medicinal chemistry research and drug discovery.

Upstream product

• 107-20-0 2-chloroethanal 
• 944401-77-8 4-fluoropyridin-2-amine 
• 74-86-2 acetylene 

Downstream Products

• 1263058-67-8 7-fluoro-3-bromoimidazo[1,2-a]pyridine 

Relevant articles and documents

HPK1 ANTAGONISTS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of HPK1, and the treatment of HPK1-mediated disorders.

Synthesis method of 7-fluoroimidazo [1, 2-A] pyridine

The invention discloses a synthesis method of 7-fluoroimidazo [1, 2A] pyridine, which comprises the following steps: by using 4fluoropyridine 2amine as a raw material, adding a chloroacetaldehyde water solution and alkali into a solvent at 35 DEG C, reacting in a micro-channel reactor for 510 minutes, and acidifying to obtain salt, thereby obtaining oxalate of 7fluoroimidazo [1, 2A] pyridine; thepreparation method comprises the following steps: dispersing oxalate in dichloromethane, and sequentially carrying out dissociation, purification and concentration to obtain the pure final product 7fluoroimidazo [1, 2A] pyridine. The synthetic method is short in route, raw materials are easy to obtain, operation is easy, and the conversion rate and safety are effectively improved. Post-treatment operation is simple, column chromatography treatment is not needed after each step of reaction, the product can be purified only through salification and dissociation, few waste materials are generatedin the production process, the environment-friendly requirement is met, and the method has important reference and practical value for actual enlarged production.