1260903-17-0

Basic information

• Product Name: 7-Fluoro-imidazo[1,2-a]pyridine
• Synonyms: 7-Fluoro-imidazo[1,2-a]pyridine
• CAS NO: 1260903-17-0
• Molecular Formula: C7H5FN2
• Molecular Weight: 136.1264032
• Mol File: 1260903-17-0.mol

Chemical Properties

• Appearance: /
• Density: 1.27±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 5.74±0.50(Predicted)
• CAS DataBase Reference: 7-Fluoro-imidazo[1,2-a]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Fluoro-imidazo[1,2-a]pyridine(1260903-17-0)
• EPA Substance Registry System: 7-Fluoro-imidazo[1,2-a]pyridine(1260903-17-0)

Safety Data

• Hazardous Substances Data: 1260903-17-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
7-Fluoro-imidazo[1,2-a]pyridine is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure and properties allow it to serve as a versatile precursor in the development of new drugs, enhancing the therapeutic potential of medications.
Used in Agrochemical Industry:
7-Fluoro-imidazo[1,2-a]pyridine is utilized as a key component in the production of agrochemicals, particularly in the creation of pesticides and fungicides. Its potential biological activities, such as antibacterial and antifungal properties, contribute to the effectiveness of these products in protecting crops and managing pests.
Used in Medicinal Chemistry Research:
7-Fluoro-imidazo[1,2-a]pyridine is employed as a valuable tool in medicinal chemistry research, where it aids in the exploration of new chemical entities and the optimization of drug candidates. Its unique structure and reactivity facilitate the discovery of novel therapeutic agents with improved efficacy and selectivity.
Used in Drug Discovery:
7-Fluoro-imidazo[1,2-a]pyridine plays a crucial role in drug discovery, where it is used to identify and develop new compounds with potential therapeutic applications. Its diverse chemical reactivity and biological activities make it an attractive starting point for the design and synthesis of innovative drugs.

Upstream product

• 944401-77-8 4-fluoropyridin-2-amine 
• 74-86-2 acetylene 
• 107-20-0 2-chloroethanal 

Downstream Products

• 1263058-67-8 7-fluoro-3-bromoimidazo[1,2-a]pyridine 

Relevant articles and documents

HPK1 ANTAGONISTS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of HPK1, and the treatment of HPK1-mediated disorders.

Synthesis method of 7-fluoroimidazo [1, 2-A] pyridine

The invention discloses a synthesis method of 7-fluoroimidazo [1, 2A] pyridine, which comprises the following steps: by using 4fluoropyridine 2amine as a raw material, adding a chloroacetaldehyde water solution and alkali into a solvent at 35 DEG C, reacting in a micro-channel reactor for 510 minutes, and acidifying to obtain salt, thereby obtaining oxalate of 7fluoroimidazo [1, 2A] pyridine; thepreparation method comprises the following steps: dispersing oxalate in dichloromethane, and sequentially carrying out dissociation, purification and concentration to obtain the pure final product 7fluoroimidazo [1, 2A] pyridine. The synthetic method is short in route, raw materials are easy to obtain, operation is easy, and the conversion rate and safety are effectively improved. Post-treatment operation is simple, column chromatography treatment is not needed after each step of reaction, the product can be purified only through salification and dissociation, few waste materials are generatedin the production process, the environment-friendly requirement is met, and the method has important reference and practical value for actual enlarged production.

Synthesis method of 7-fluoroimidazole[1, 2-a]pyridine promoted by copper complex

The invention belongs to the field of organic synthesis, fine chemicals and medical intermediates, and particularly relates to a synthesis method of 7-fluoroimidazole[1, 2-a]pyridine from 2-amino-4-fluoropyridine and acetylene promoted by a copper complex. The method is characterized in that a copper complex is used as a catalyst, and 2-amino-4-fluoropyridine and acetylene undergo an oxidative cycloaddition reaction in the presence of a peroxide, so that 7-fluoroimidazole[1, 2-a]pyridine is synthesized. The method has the advantages of simple operation, cheap and easily available reagents, andgood industrial application prospect.