1261031-46-2

Upstream product

• 106824-49-1 2-phenylethynylbenzaldehyde oxime 
• 1068146-62-2 4-bromo-3-phenylisoquinoline N-oxide 
• 538-75-0 dicyclohexyl-carbodiimide 

Downstream Products

• 1261032-08-9 1,3-dicyclohexyl-1-(3,4-diphenylisoquinolin-1-yl)urea 
• 1261032-10-3 C₃₅H₃₉N₃O₂ 
• 1261032-09-0 C₃₅H₃₉N₃O 
• 1261032-11-4 C₃₄H₃₆FN₃O 

Relevant academic research and scientific papers

Facile assembly of 1-(4-haloisoquinolin-1-yl)ureas via a reaction of 2-alkynylbenzaldoxime, carbodiimide, and halide in water

1-(4-Haloisoquinolin-1-yl)ureas are generated efficiently via a tandem reaction of 2-alkynylbenzaldoxime, carbodiimide, with halide in water. The process involves the generation of halonium ion in situ by employment of NaI/oxone or NaBr/oxone as the promoters. This green process proceeds smoothly and efficiently, accommodating a variety of substituents to generate the desired products.

1-(isoquinolin-1-yl)urea library generation via three-component reaction of 2-alkynylbenzaldoxime, carbodiimide, with electrophile

A novel and highly efficient three-component reaction of 2-alkynylbenzaldoxime, carbodiimide, with electrophile (bromine or iodine monochloride) is disclosed, which generates 1-(4-haloisoquinolin-1-yl)ureas in good yields under mild conditions. Subsequent