1261060-39-2Relevant academic research and scientific papers
Cobalt-catalyzed ortho-Alkylation of secondary benzamide with alkyl chloride through directed C-H bond activation
Chen, Quan,Ilies, Laurean,Nakamura, Eiichi
, p. 428 - 429 (2011)
Coupling of an alkyl chloride with a secondary benzamide derivative at the ortho-position can be achieved in good to excellent yield in the presence of a cobalt catalyst and cyclohexylmagnesium chloride in diethyl ether at room temperature. Cyclohexylmagnesium chloride formally acts to remove hydrogen atoms from the amide nitrogen and from the ortho-position and to generate the active cobalt species.
