701-49-5

Usage

Uses

Used in Research Applications:
4-Fluoro-N-methylbenzamide is utilized as a research chemical for its distinctive properties, facilitating studies in various scientific fields.
Used in Pharmaceutical Applications:
In the pharmaceutical industry, 4-Fluoro-N-methylbenzamide serves as a key intermediate in the synthesis of various drug compounds, contributing to the development of new medications.
Used in Organic Synthesis:
4-Fluoro-N-methylbenzamide is employed as a building block in organic synthesis, enabling the creation of a range of chemical compounds with diverse applications.
Used in the Preparation of Pharmaceutical Intermediates:
4-Fluoro-n-methylbenzamide is also used as a precursor in the preparation of pharmaceutical intermediates, playing a crucial role in the production of various medicinal agents.
The potential pharmacological activities of 4-Fluoro-N-methylbenzamide are currently under investigation, which may lead to further applications in the medical field.

InChI:InChI=1/C8H8FNO/c1-10-8(11)6-2-4-7(9)5-3-6/h2-5H,1H3,(H,10,11)

Upstream product

• 403-43-0 4-fluorobenzoyl chloride 
• 74-89-5 methylamine 
• 421-20-5 Methyl fluorosulfonate 
• 1194-02-1 4-fluorobenzonitrile 
• 325980-20-9 N-benzyl-N-methyl-4-fluorobenzamide 
• 824-75-9 p-fluorobenzamide 
• 80-43-3 bis(1-methyl-1-phenylethyl)peroxide 
• 405-66-3 (4-Fluoro-benzyl)-methyl-amine 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 13939-06-5 molybdenum hexacarbonyl 
• 456-22-4 4-Fluorobenzoic acid 
• 593-51-1 methylamine hydrochloride 
• 116332-54-8 4-fluoro-N-methoxy-N-methylbenzamide 

Downstream Products

• 52893-48-8 Trifluormethyl-p-fluorbenzoat 
• 52893-52-4 4-Fluoro-N-methyl-benzimidic acid ethyl ester 
• 82791-56-8 1-(4-Fluoro-phenyl)-6,7-dimethoxy-2-methyl-2H-isoquinolin-3-one 
• 1067902-24-2 4-(9-Benzyl-3,9-diazaspiro[5.5]undec-3-yl)-N-methylbenzamide 
• 1315257-13-6 6-fluoro-2-methyl-3,4-diphenylisoquinolin-1(2H)-one 
• 1235478-87-1 6-methoxy-2-methyl-3,4-diphenylisoquinolin-1(2H)-one 
• 1416562-29-2 4-cyclopropyl-6-fluoro-2-methyl-3-phenylisoquinolin-1(2H)-one 
• 1416562-30-5 3-cyclopropyl-6-fluoro-2-methyl-4-phenylisoquinolin-1(2H)-one 
• 1246083-87-3 N-methyl-4-(4-((2-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)benzamide 
• 1246084-19-4 4-(4-((2,8-dimethyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)-N-methylbenzamide 
• 1246083-26-0 4-(4-((8-methoxy-2-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)-N-methylbenzamide 
• 1426954-55-3 4-fluoro-N-formylbenzamide 
• 1178339-86-0 N-(cyclohexylmethyl)-4-fluorobenzamide 

Relevant academic research and scientific papers

The Pd-catalyzed synthesis of difluoroethyl and difluorovinyl compounds with a chlorodifluoroethyl iodonium salt (CDFI)

Herein, we report a simple and efficient method for the direct installation of chlorodifluoroethyl group onto aromatic molecules of various aromatic amides with a new 2-chloro,2,2-difluoroethyl(mesityl)iodonium salt (CDFI). Moreover, the chlorodifluoroeth

Assemblies of 1,4-Bis(diarylamino)naphthalenes and Aromatic Amphiphiles: Highly Reducing Photoredox Catalysis in Water

Host-guest assemblies of a designed 1,4-bis(diarylamino)naphthalene and V-shaped aromatic amphiphiles consisting of two pentamethylbenzene moieties bridged by an m -phenylene unit bearing two hydrophilic side chains emerged as highly reducing photoredox catalysis systems in water. An efficient demethoxylative hydrogen transfer of Weinreb amides has been developed. The present supramolecular strategy permits facile tuning of visible-light photoredox catalysis in water.

Rhodium-Catalyzed Electrooxidative C?H Olefination of Benzamides

Metal-catalyzed chelation-assisted C?H olefinations have emerged as powerful tools for the construction of functionalized alkenes. Herein, we describe the rhoda-electrocatalyzed C?H activation/alkenylation of arenes. The olefinations of challenging electron-poor benzamides were thus accomplished in a fully dehydrogenative fashion under electrochemical conditions, avoiding stoichiometric chemical oxidants, and with H2 as the only byproduct. This versatile alkenylation reaction also features broad substrate scope and used electricity as a green oxidant.

Dealkoxylation ofN-alkoxyamides without an external reductant driven by Pd/Al cooperative catalysis

Lewis acid-assisted palladium-catalysed dealkoxylation ofN-alkoxyamides has been developed. This reaction proceeded smoothly with a range ofN-alkoxyamides in the absence of an external reductant, thereby establishing a convenient and reductant-free protocol. In addition, a gram-scale reaction could be achieved. Preliminary mechanistic investigations indicated that β-hydrogen elimination from a palladium alkoxide intermediate generated an intramolecular hydride source.

Rhenium-Catalyzed Phthalide Synthesis from Benzamides and Aldehydes via C-H Bond Activation

The [4 + 1] annulation of benzamides and aldehydes for phthalide synthesis was achieved via rhenium-catalyzed C-H activation, which demonstrates an unprecedented reaction pattern distinct from those of other transition-metal catalyses. The reaction also features readily available starting materials, a wide scope for both electro-rich and electro-deficient substrates, and the elimination of homoannulation byproducts.

Chemoselective Synthesis of Aryl Ketones from Amides and Grignard Reagents via C(O)-N Bond Cleavage under Catalyst-Free Conditions

Conversion of a wide range of N-Boc amides to aryl ketones was achieved with Grignard reagents via chemoselective C(O)-N bond cleavage. The reactions proceeded under catalyst-free conditions with different aryl, alkyl, and alkynyl Grignard reagents. α-Ketoamide was successfully converted to aryl diketones, while α,β-unsaturated amide underwent 1,4-addition followed by C(O)-N bond cleavage to provide diaryl propiophenones. N-Boc amides displayed higher reactivity than Weinreb amides with Grignard reagents. A broad substrate scope, excellent yields, and quick conversion are important features of this methodology.

Visible-Light-Driven Oxidation of N -Alkylamides to Imides Using Oxone/H 2 O and Catalytic KBr

Imides are prepared conveniently by visible-light-driven oxidations of various N -alkylamides under mild conditions. The majority of the reactions proceed efficiently by using Oxone as the oxidant in the presence of a catalytic amount of KBr in H 2 O/CH 2 Cl 2 under irradiation by an 8 W white LED at room temperature. Experimental studies suggest that an imine, obtained from the substrate amide via a radical process, is the key intermediate.

Palladium-Catalyzed Direct C-H Trifluoroethylation of Aromatic Amides

A simple and direct C-H trifluoroethylation of aromatic amides has been developed. The protocol is applicable to a variety of aromatic amides, including ones derived from amino acids. The developed method can be used for further modifications of peptides. Preliminary mechanistic studies have been done by isolating the reaction intermediate.

I2-Catalyzed Oxidative Amidation of Benzylamines and Benzyl Cyanides under Mild Conditions

We report a novel and efficient method for the oxidation of benzylic carbons (amines and cyanides) into corresponding benzamides using a catalytic amount of I2 and TBHP as the green oxidant via the C-H bond cleavage of the benzylic carbon under mild reaction conditions. According to the literature survey, this is the first report for the oxidative amidation of benzylamines and decyanation of benzyl cyanides in one pot under metal-free conditions.

Aerobic thiyl radical addition/cyclization of N-methacryloyl benzamides for the synthesis of isoquinoline-1,3(2H,4H)-dione derivatives

A highly effective oxidative thiyl radical addition/cyclization of N-methacryloylbenzamides was explored using dioxygen as the sole terminal oxidant without the use of precious and/or toxic transition-metal catalysts. This method provides convenient access to a variety of useful sulfide-containing 4,4-disubstituted isoquinoline-1,3-diones by constructing C-S and C-C bonds in one step.