1261063-49-3Relevant academic research and scientific papers
Friedel-Crafts amidoalkylation via thermolysis and oxidative photocatalysis
Dai, Chunhui,Meschini, Francesco,Narayanam, Jagan M. R.,Stephenson, Corey R. J.
experimental part, p. 4425 - 4431 (2012/06/30)
Friedel-Crafts amidoalkylation was achieved by oxidation of dialkylamides using persulfate (S2O82-) in the presence of the visible light catalyst, Ru(bpy)3Cl2, at room temperature, via a reactive N-acyliminium intermediate. Alternatively, mild heating of the dialkylamides and persulfate afforded a metal and Lewis acid-free Friedel-Crafts amidoalkylation. Alcohols and electron-rich arenes served as effective nucleophiles, forming new C-O or C-C bonds. In general, photocatalysis provided higher yields and better selectivities.
Iron-catalyzed oxidative coupling of alkylamides with arenes through oxidation of alkylamides followed by Friedel-Crafts alkylation
Shirakawa, Eiji,Uchiyama, Nanase,Hayashi, Tamio
scheme or table, p. 25 - 34 (2011/03/22)
FeCl3 in combination with t-BuOOt-Bu as an oxidant was found to be an efficient catalyst for oxidation of alkylamides to α-(tert-butoxy) alkylamides. FeCl2 and CuCl showed, respectively, almost the same and slightly lower activities
