1261077-99-9Relevant academic research and scientific papers
A magnetic metal-organic framework as a highly active heterogeneous catalyst for one-pot synthesis of 2-substituted alkyl and aryl(indolyl)kojic acid derivatives
Zhang, Hong-Yan,Hao, Xiao-Peng,Mo, Li-Ping,Liu, Sha-Sha,Zhang, Wen-Bo,Zhang, Zhan-Hui
, p. 7108 - 7115 (2017/08/02)
A novel magnetic metal-organic framework, NiFe2O4@MOF-5, has been prepared and characterized using spectroscopic, microscopic, and magnetic techniques (FT-IR, XRD, TEM, SEM, EDX, and VSM). This magnetically separable catalyst exhibit
Synthesis of FAU zeolite nanoparticles as heterogeneous catalyst for one-pot synthesis of 2-substituted Aryl (Indolyl) Kojic acid derivatives under solvent-free condition
Sadeghi, Bahareh,Lasemi, Zahra,Amiri Tavasoli, Fereshteh,Hashemian, Saeedeh,Zahedi, Hesam
, p. 1497 - 1503 (2014/06/24)
FAU zeolite nanoparticles have been found to be a highly efficient and versatile catalyst for preparation of 2-substituted aryl (indolyl) kojic acid derivatives through one-pot condensation of kojic acid with aryl aldehydes and indoles under solvent-free
Synthesis of heteroaryl/aryl kojic acid conjugates as stimulators of glucose uptake by GLUT4 translocation
Sharma, Deepak K.,Pandey, Jyotsana,Tamrakar, Akhilesh K.,Mukherjee, Debaraj
, p. 727 - 736 (2014/10/15)
Insulin exerts its metabolic actions through the insulin receptor (IR) and plays an essential role in treatment of diabetes. The inconvenience of daily injections and the undesirable side-effects associated with insulin injections demand novel drugs for the disease. To search for bioactive insulin mimetic, we synthesized a chemical library of small molecules (2a-3f) based on the indolylkojic acid scaffold (B). An In vitro screening assay was performed to stimulate glucose transport in rat L6 skeletal muscle cells, post treatment of the compounds (2a-3f) for the time period incubation of 16 h. Compounds 2f, 2g, 2l, 3a, 3b, 3c and 3d have shown significant glucose uptake stimulation as compared to the controls at micromolar concentrations. In mechanistic studies, we observed that these compounds exert their biological action by enhancing GLUT4 translocation to cell surface via PI3K-dependent signalling pathway in agreement to the insulin mode of action. Hence, these promising conjugates should be useful for further drug development in diabetes treatment.
Indium(III) chloride catalyzed three-component coupling reaction: A novel synthesis of 2-substituted aryl(indolyl)kojic acid derivatives as potent antifungal and antibacterial agents
Reddy, B.V. Subba,Reddy, M. Ramana,Madan, Ch.,Kumar, K. Pranay,Rao, M. Srinivasa
experimental part, p. 7507 - 7511 (2011/02/22)
Three-component coupling of aldehyde, indole and kojic acid has been achieved using a catalytic amount of InCl3 under solvent free conditions to produce a novel series of 2-substituted aryl(indolyl)kojic acid derivatives in good yields and with
