1261080-71-0

Basic information

• Product Name: 2-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)thiazole-5-carboxylic acid
• Synonyms: 2-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)thiazole-5-carboxylic acid
• CAS NO: 1261080-71-0
• Molecular Weight: 385.424
• Mol File: 1261080-71-0.mol

Chemical Properties

• CAS DataBase Reference: 2-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)thiazole-5-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)thiazole-5-carboxylic acid(1261080-71-0)
• EPA Substance Registry System: 2-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)thiazole-5-carboxylic acid(1261080-71-0)

Safety Data

• Hazardous Substances Data: 1261080-71-0(Hazardous Substances Data)

Upstream product

• 348640-06-2 4-bromo-7-azaindole 
• 55052-24-9 1H-Pyrrolo[2,3-b]pyridine-7-oxide 
• 1261080-70-9 ethyl 2-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-4-yl)thiazole-5-carboxylate 
• 942919-24-6 1-(phenylsulfonyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo-[2,3-b]pyridine 
• 889939-25-7 1-(benzenesulfonyl)-4-bromo-1H-pyrrolo[2,3-b]pyridine 
• 271-63-6 7-Azaindole 

Downstream Products

• 1261080-72-1 (S)-N-(1-azido-3-(2,4-dichlorophenyl)propan-2-yl)-2-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)thiazole-5-carboxamide 
• 1261080-57-2 (S)-N-(1-amino-3-(2,4-dichlorophenyl)propan-2-yl)-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiazole-5-carboxamide 
• 1261080-73-2 (S)-N-(1-azido-3-(2,4-dichlorophenyl)propan-2-yl)-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiazole-5-carboxamide 

Relevant articles and documents

5 - thiazole amides and biological applications

The invention relates to a 5-thiazole amide compound and biology application thereof. The 5-thiazole amide compound has a general formula (I) described in the specification and is used for targeting an AKT/PKB kinase (ATP binding site). Experiments prove that a thiazole amide AKT inhibitor can remarkably inhibit the activity of the AKT kinase in vitro and has strong proliferation inhibition function on various tumor cells with high AKT activity, which indicate that the 5-thiazole amide compound can be used for preparing drugs for resisting tumors.

New thiazole carboxamides as potent inhibitors of Akt kinases

A new series of 2-substituted thiazole carboxamides were identified as potent pan inhibitors against all three isoforms of Akt (Akt1, Akt2 and Akt3) by systematic optimization of weak screening hit N-(1-amino-3-phenylpropan-2-yl)- 2-phenylthiazole-5-carboxamide (1). One of the most potent compounds, 5m, inhibited the kinase activities of Akt1, Akt2 and Akt3 with IC50 values of 25, 196 and 24 nM, respectively. The compound also potently inhibited the phosphorylation of downstream MDM2 and GSK3β proteins, and displayed strongly antiproliferative activity in prostate cancer cells. The inhibitors might serve as lead compounds for further development of novel effective anticancer agents.