1261145-34-9Relevant academic research and scientific papers
Design, synthesis, and biological and docking studies of novel epipodophyllotoxin-chalcone hybrids as potential anticancer agents
Banday, Abid Hussain,Kulkarni, Vinod V.,Hruby, Victor J.
, p. 94 - 104 (2015/02/18)
A series of new compounds consisting of epipodophyllotoxin-chalcone hybrids was synthesized towards the development of better anticancer lead molecules. These hybrids consist of structurally different but functionally similar topoisomerase-II inhibitors which were conjugated together through click-chemistry. Their design is aimed at the synthesis of novel chemotherapeutics with a better target-protein interaction and higher bioavailability. Evaluation of the anticancer activity of these designed conjugates against a panel of six human cancer cell lines proved their potential cytotoxicity. Further, these compounds were docked against topoisomerase-II and the energy calculations were in good agreement with the observed IC50 values. Compounds 6d, 6f, 7d and 7f exhibited significant in vitro cytotoxicity. Among all the compounds evaluated, compound 7f was found to be the most promising, especially selective against SW-620 and SKN-SH cell lines. This journal is
Design, synthesis and in vitro antimalarial evaluation of triazole-linked chalcone and dienone hybrid compounds
Guantai, Eric M.,Ncokazi, Kanyile,Egan, Timothy J.,Gut, Jiri,Rosenthal, Philip J.,Smith, Peter J.,Chibale, Kelly
experimental part, p. 8243 - 8256 (2011/02/25)
A targeted series of chalcone and dienone hybrid compounds containing aminoquinoline and nucleoside templates was synthesized and evaluated for in vitro antimalarial activity. The Cu(I)-catalyzed cycloaddition of azides and terminal alkynes was applied as
