126117-45-1Relevant articles and documents
Triarylantimony Dicaroxylates Ar3Sb[OC(O)R]2 (Ar = Ph, p-Tol; R = 2-C4H3O, 3-C5H4N): Synthesis and Structure
Sharutin,Sharutina,Pakusina,Platonova,Zhidkov,Pushilin,Gerasimenko
, p. 694 - 702 (2003)
Bis(2-furoinate)triphenyl- and tri-p-tolylantimony and bis(3-niacinate) triphenylanitmony were synthesized by reacting triarylantimony (Ar 3Sb; Ar = Ph, p-Tol) with 2-furancarboxylic and 3-pyridinecarboxylic acids in the presence of hydrogen peroxide. According to X-ray diffraction data, Sb atoms have trigonal bipyramidal coordination polyhedra. The Sb-O distances are 2.117(4), 2.137(4) A; 2.136(2), 2.158(2) A, and 2.112(1), 2.101(2) A, the Sb...O distances are 2.866(4), 2.798(4) A; 2.816(2), 2.774(2) A, and 3.054(2), 3.168(2) A, respectively.
Anti-leishmanial activity of heteroleptic organometallic Sb(v) compounds
Ali, Muhammad Irshad,Rauf, Muhammad Khawar,Badshah, Amin,Kumar, Ish,Forsyth, Craig M.,Junk, Peter C.,Kedzierski, Lukasz,Andrews, Philip C.
supporting information, p. 16733 - 16741 (2013/12/04)
In seeking new drugs for the treatment of the parasitic disease Leishmaniasis, an extensive range of organometallic antimony(v) dicarboxylates of the form [SbR3(O2CR′)2] have been synthesised, characterised and evaluated. The organometallic moieties (R) in the complexes vary in being Ph, tolyl (o, m or p), or benzyl. The carboxylates are predominantly substituted benzoates with some compounds incorporating acetato or cinnamato ligands. The crystal structures of [Sb(p-Tol)3(O 2CC6H2-3,4,5-(OMe)3) 2]·0.5PhMe and [SbPh3(m-CH3C 6H4CH2CO2)2] were determined and shown to adopt a typical trigonal pyramidal geometry, being monomeric with a five coordinate Sb centre. In total, the biological activity of 26 Sb(v) compounds was assessed against the Leishmania major parasite, and also human fibroblast skin cells to give a measure of general toxicity. Of these, 11 compounds (predominantly substituted benzoates with m- or p-tolyl ligands) proved to be highly effective against the parasite amastigotes at concentrations of 0.5-3.5 μM, while being non-toxic towards the mammalian cells at levels below 25 μM, making them highly promising drug candidates.
