1261242-21-0

Basic information

• Product Name: C₁₁H₁₇N₃O₂S
• Synonyms: C₁₁H₁₇N₃O₂S
• CAS NO: 1261242-21-0
• Molecular Weight: 255.341
• Mol File: 1261242-21-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: C₁₁H₁₇N₃O₂S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₁H₁₇N₃O₂S(1261242-21-0)
• EPA Substance Registry System: C₁₁H₁₇N₃O₂S(1261242-21-0)

Safety Data

• Hazardous Substances Data: 1261242-21-0(Hazardous Substances Data)

Upstream product

• 1261242-18-5 C₁₉H₂₃N₃O₄S 
• 144432-72-4 2-benzyl-1,2,5-thiadiazolidine 1,1-dioxide 
• 4152-09-4 N-benzylethylenediamine 

Downstream Products

• 1261242-39-0 C₂₆H₂₄FN₇O₂S₂ 

Relevant articles and documents

Discovery of New Imidazo[2,1- b]thiazole Derivatives as Potent Pan-RAF Inhibitors with Promising in Vitro and in Vivo Anti-melanoma Activity

BRAF is an important component of MAPK cascade. Mutation of BRAF, in particular V600E, leads to hyperactivation of the MAPK pathway and uncontrolled cellular growth. Resistance to selective inhibitors of mutated BRAF is a major obstacle against treatment of many cancer types. In this work, a series of new (imidazo[2,1-b]thiazol-5-yl)pyrimidine derivatives possessing a terminal sulfonamide moiety were synthesized. Pan-RAF inhibitory effect of the new series was investigated, and structure-activity relationship is discussed. Antiproliferative activity of the target compounds was tested against the NCI-60 cell line panel. The most active compounds were further tested to obtain their IC50 values against cancer cells. Compound 27c with terminal open chain sulfonamide and 38a with a cyclic sulfamide moiety showed the highest activity in enzymatic and cellular assay, and both compounds were able to inhibit phosphorylation of MEK and ERK. Compound 38a was selected for testing its in vivo activity against melanoma. Cellular and animal activities are reported.

Synthesis of new 6-(4-Fluorophenyl)-5-(2-substituted pyrimidin-4-yl) imidazo[2,1-b] thiazole derivatives and their antiproliferative activity against melanoma cell line

Synthesis of a new series of pyrimidinyl-imidazo[2,1-b]thiazole derivatives is described. Their antiproliferative activity against A375 human melanoma cell line was tested and the effect of substituents on the pyrimidinyl ring side chain was investigated.