1261244-50-1

Basic information

• Product Name: (E)-1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-one
• Synonyms: (E)-1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-one
• CAS NO: 1261244-50-1
• Molecular Weight: 400.484
• Mol File: 1261244-50-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-one(1261244-50-1)
• EPA Substance Registry System: (E)-1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-one(1261244-50-1)

Safety Data

• Hazardous Substances Data: 1261244-50-1(Hazardous Substances Data)

Upstream product

• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 17610-24-1 1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalenyl)ethanone 

Relevant articles and documents

Synthesis and biological evaluation of retinoid-chalcones as inhibitors of colon cancer cell growth

Based on the observed anticancer activity of chalcones and retinoids, a novel class of retinoid-chalcone hybrids was designed and synthesized. As part of our ongoing studies to discover natural product based anticancer compounds, the retinoid-chalcone hybrids were tested against the colon cancer cell line HT-29. Retinoid like moiety was introduced through Friedel-Crafts alkylation of toluene. Among the synthesized compounds, the cyano derivative (E)-3-(3-oxo-3-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl) prop-1-enyl)benzonitrile 8 showed submicromolar inhibitory activity with an IC50 of 0.66 μM.