17610-24-1

Basic information

• Product Name: 1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthyl)ethan-1-one
• Synonyms: 1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthyl)ethan-1-one;1,1,4,4,6-Pentamethyl-7-acetyl-1,2,3,4-tetrahydronaphthalene;1-[(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethylnaphthalen)-2-yl]ethanone;5',6',7',8'-Tetrahydro-3',5',5',8',8'-pentamethyl-2'-acetonaphthone;Einecs 241-585-4;Ethanone, 1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)-;6-ACETYL-1,1,4,4,7-PENTAMETHYL-1,2,3,4-TETRAHYDRONAPHTHALENE;1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethanone
• CAS NO: 17610-24-1
• Molecular Formula: C₁₇H₂₄O
• Molecular Weight: 244.37186
• EINECS: 241-585-4
• Mol File: 17610-24-1.mol
• Article Data: 13

Chemical Properties

• Melting Point: 62-63.5 °C(Solv: ethanol (64-17-5))
• Boiling Point: 347.6°Cat760mmHg
• Flash Point: 146.3°C
• Appearance: /
• Density: 0.936g/cm³
• Vapor Pressure: 5.34E-05mmHg at 25°C
• Refractive Index: 1.498
• CAS DataBase Reference: 1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthyl)ethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthyl)ethan-1-one(17610-24-1)
• EPA Substance Registry System: 1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthyl)ethan-1-one(17610-24-1)

Safety Data

• Hazardous Substances Data: 17610-24-1(Hazardous Substances Data)

Usage

General Description

1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthyl)ethan-1-one is a complex organic compound with the chemical formula C17H24O. It is a ketone with a unique structure containing a naphthalene ring and multiple methyl groups. This chemical is commonly used in the production of fragrances and flavors due to its strong and long-lasting scent. It is known for its musky, woody, and citrusy aroma and is often used in perfumes, colognes, and other scented products. Additionally, it may have applications in the pharmaceutical and cosmetic industries due to its specific chemical properties and fragrance characteristics. Overall, 1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthyl)ethan-1-one is a versatile and valuable chemical with various potential uses.

InChI:InChI=1/C17H24O/c1-11-9-14-15(10-13(11)12(2)18)17(5,6)8-7-16(14,3)4/h9-10H,7-8H2,1-6H3

Upstream product

• 110-03-2 2,5-dimethyl-2,5-hexanediol 
• 6223-78-5 2,5-dichloro-2,5-dimethyl hexane 
• 6683-48-3 1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene 
• 96042-30-7 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran 
• 75-36-5 acetyl chloride 

Downstream Products

• 1261244-63-6 (E)-3-(3-hydroxy-4-methoxyphenyl)-1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-2-en-1-one 
• 1261244-50-1 (E)-1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-one 
• 1261244-58-9 (E)-3-(3,5-dimethoxyphenyl)-1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-2-en-1-one 
• 1261244-47-6 (E)-3-(3-oxo-3-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-1-enyl)benzonitrile 
• 1261244-60-3 (E)-3-(3-nitrophenyl)-1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-2-en-1-one 
• 1261244-52-3 (E)-3-(4-nitrophenyl)-1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-2-en-1-one 
• 1261244-46-5 C₂₄H₂₈O 
• 1261244-64-7 (E)-3-(4-hydroxyphenyl)-1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-2-en-1-one 
• 1261244-48-7 (E)-3-(4-methoxyphenyl)-1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-2-en-1-one 
• 1261244-59-0 (E)-3-(3,4-dimethoxyphenyl)-1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-2-en-1-one 
• 1261244-54-5 (E)-3-(3-hydroxyphenyl)-1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-2-en-1-one 
• 1261244-51-2 (E)-3-(4-bromophenyl)-1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-2-en-1-one 
• 1261244-45-4 C₂₅H₂₇NO 
• 1261244-53-4 (E)-3-(4-(dimethylamino)phenyl)-1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-2-en-1-one 

Relevant articles and documents

Bromomethyl Silicate: A Robust Methylene Transfer Reagent for Radical-Polar Crossover Cyclopropanation of Alkenes

A general protocol for visible-light-induced cyclopropanation of alkenes was developed with bromomethyl silicate as a methylene transfer reagent, offering a robust tool for accessing highly valuable cyclopropanes. In addition to α-aryl or methyl-substituted Michael acceptors and styrene derivatives, the unactivated 1,1-dialkyl ethylenes were also shown to be viable substrates. Apart from realizing the cyclopropanation of terminal alkenes, the methyl transfer reaction has been further demonstrated to be amenable to the internal olefins. The photocatalytic cyclopropanation of 1,3-bis(1-arylethenyl)benzenes was also achieved, giving polycyclopropane derivatives in excellent yields. With late-stage cyclopropanation as the key strategy, the synthetic utility of this transformation was also demonstrated by the total synthesis of LG100268.

Synthesis and biological evaluation of retinoid-chalcones as inhibitors of colon cancer cell growth

Based on the observed anticancer activity of chalcones and retinoids, a novel class of retinoid-chalcone hybrids was designed and synthesized. As part of our ongoing studies to discover natural product based anticancer compounds, the retinoid-chalcone hybrids were tested against the colon cancer cell line HT-29. Retinoid like moiety was introduced through Friedel-Crafts alkylation of toluene. Among the synthesized compounds, the cyano derivative (E)-3-(3-oxo-3-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl) prop-1-enyl)benzonitrile 8 showed submicromolar inhibitory activity with an IC50 of 0.66 μM.

Ketone precursors for organoleptic compounds

The invention discloses ketones of formula I: wherein, Y is an optionally substituted alkyl, cycloalkyl, or cycloalkylalkyl, wherein each alkyl group is straight or branched and each alkyl and cycloalkyl group is saturated or unsaturated; R1is hydrogen or a C1-6alkyl group that is substituted, saturated or unsaturated, straight or branched; A is a chromophoric substituted aromatic ring or ring system; n is an integer; and with the proviso that formula I is not 2-ethoxy-1-phenyl-ethanone. These compositions are useful for the delivery of organoleptic compounds, especially of flavors, fragrances, masking agents and antimicrobial compounds.