1261266-23-2Relevant academic research and scientific papers
Synthesis of novel curcumin analogues for inhibition of 11β-hydroxysteroid dehydrogenase type 1 with anti-diabetic properties
Yuan, Xiaohuan,Li, Hongzhi,Bai, He,Su, Zhijian,Xiang, Qi,Wang, Chaonan,Zhao, Binghai,Zhang, Yufei,Zhang, Qihao,Chu, Yanhui,Huang, Yadong
, p. 223 - 230 (2014/04/03)
In the present study, a series of mono-carbonyl analogues of curcumin were designed and synthesized by deleting the reactive beta-diketone moiety, which is responsible for the pharmacokinetic limitation of curcumin. We demonstrated that 4 of 9 curcumin an
Synthesis and anti-inflammatory evaluation of novel mono-carbonyl analogues of curcumin in LPS-stimulated RAW 264.7 macrophages
Zhao, Chengguang,Cai, Yuepiao,He, Xuzhi,Li, Jianling,Zhang, Li,Wu, Jianzhang,Zhao, Yunjie,Yang, Shulin,Li, Xiaokun,Li, Wulan,Liang, Guang
experimental part, p. 5773 - 5780 (2011/02/22)
Curcumin is a multifunctional natural product with regulatory effects on inflammation. However, a major limitation for the application of curcumin is its poor bioavailability. We previously demonstrated that the mono-carbonyl analogues of curcumin possess
