60611-24-7

Basic information

• Product Name: 2-FLUORO-6-(TRIFLUOROMETHYL)BENZALDEHYDE
• Synonyms: OTF-BAD-6F;2-FLUORO-6-(TRIFLUOROMETHYL)BENZALDEHYDE;alpha,alpha,alpha,6-Tetrafluoro-o-tolualdehyde;à,à,à,6-tetrafluoro-o-tolualdehyde;2-Fluoro-6-(trifluoromethyl)benzaldehyde 97%;2-Fluoro-6-(trifluoromethyl)benzaldehyde97%;α,α,α,6-Tetrafluoro-2-tolualdehyde;α,α,α,6-Tetrafluoro-o-tolualdehyde
• CAS NO: 60611-24-7
• Molecular Formula: C₈H₄F₄O
• Molecular Weight: 192.11
• EINECS: -0
• Product Categories: Benzaldehyde;Aldehydes;C8;Carbonyl Compounds;Fluorine series
• Mol File: 60611-24-7.mol
• Article Data: 6

Chemical Properties

• Melting Point: 155-157°C
• Boiling Point: 156 °C(lit.)
• Flash Point: 179 °F
• Appearance: /
• Density: 1.432 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.572mmHg at 25°C
• Refractive Index: n20/D 1.458(lit.)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Sensitive: Air Sensitive
• BRN: 2263481
• CAS DataBase Reference: 2-FLUORO-6-(TRIFLUOROMETHYL)BENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-6-(TRIFLUOROMETHYL)BENZALDEHYDE(60611-24-7)
• EPA Substance Registry System: 2-FLUORO-6-(TRIFLUOROMETHYL)BENZALDEHYDE(60611-24-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 60611-24-7(Hazardous Substances Data)

Usage

Uses

2-Fluoro-6-(trifluoromethyl)benzaldehyde may be employed for the synthesis of diaryl ether, 2-(3,5-dimethoxyphenoxy)-6-(trifluoromethyl)- benzonitrile and substituted benzo[b]thiophene-2-carboxylates.

General Description

2-Fluoro-6-(trifluoromethyl)benzaldehyde participates in the synthesis of 2-amino-5-trifluoromethylquinazoline.

InChI:InChI=1/C8H4F4O/c9-7-3-1-2-6(5(7)4-13)8(10,11)12/h1-4H

Upstream product

• 401-80-9 3-fluoro-trifluoromethylbenzene 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 190273-74-6 2-amino-5-trifluoromethylquinazoline 
• 830346-46-8 N-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}urea 
• 830346-50-4 3-[(2R)-amino-2-phenylethyl]-5-(2-fluoro-3-methoxyphenyl)-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methyl-2,4(1H,3H)-pyrimidinedione trifluoroacetate 
• 832720-84-0 4-((R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-trifluoromethylbenzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-yl]-1-phenylethylamino)butyric acid ethyl ester 
• 834153-87-6 4-((R)-2-[5-(2- fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl ]-1- phenylethylamino)-butyric acid 
• 100947-75-9 5-[2-methoxy-6-(trifluoromethyl)phenyl]oxazolidine-2,4-dione 
• 100947-72-6 5-(2-Fluoro-6-trifluoromethyl-phenyl)-oxazolidine-2,4-dione 
• 146137-87-3 methyl 4-(trifluoromethyl)benzo[b]thiophene-2-carboxylate 
• 32890-94-1 2-fluoro-6-(trifluoromethyl)benzoic acid 

Relevant articles and documents

Method for preparing 2-fluoro-6-trifluoromethylbenzaldehyde by using continuous flow reaction device

The embodiment of the invention discloses a method for preparing 2-fluoro-6-trifluoromethylbenzaldehyde by using a continuous flow reaction device, and belongs to the technical field of pharmaceuticaland chemical synthesis. The method includes: reacting a

PROCESSES TO PRODUCE ELAGOLIX

The present invention relates to a scalable process for the making of elagolix, its salts and the process of intermediate compounds.

Regioselective formylation of 1,3-disubstituted benzenes through in situ lithiation

A facile method of regioselective formylation of disubstituted benzene via in situ deprotonation/metalation using n-BuLi/TMEDA/DIPA has been developed. Effect of different electron withdrawing and electron donating substituents in 1,3-interrelated aromatic system was studied; the metalation mostly occurred at the 2-position to afford the desired products in high yields.