60611-24-7

Usage

Uses

Used in Pharmaceutical Industry:
2-Fluoro-6-(trifluoromethyl)benzaldehyde is used as a key intermediate in the synthesis of various pharmaceuticals, including diaryl ethers, which are known for their diverse biological activities and potential therapeutic applications.
Used in Chemical Synthesis:
2-Fluoro-6-(trifluoromethyl)benzaldehyde is used as a starting material for the synthesis of 2-(3,5-dimethoxyphenoxy)-6-(trifluoromethyl)-benzonitrile, a compound with potential applications in the development of new drugs and agrochemicals.
Used in Organic Chemistry:
2-Fluoro-6-(trifluoromethyl)benzaldehyde is employed as a precursor in the synthesis of substituted benzo[b]thiophene-2-carboxylates, which are valuable building blocks in organic chemistry and can be used to construct a variety of complex organic molecules with potential applications in various fields.

InChI:InChI=1/C8H4F4O/c9-7-3-1-2-6(5(7)4-13)8(10,11)12/h1-4H

Upstream product

• 401-80-9 3-fluoro-trifluoromethylbenzene 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 146137-87-3 methyl 4-(trifluoromethyl)benzo[b]thiophene-2-carboxylate 
• 190273-74-6 2-amino-5-trifluoromethylquinazoline 
• 100947-72-6 5-(2-Fluoro-6-trifluoromethyl-phenyl)-oxazolidine-2,4-dione 
• 100947-75-9 5-[2-methoxy-6-(trifluoromethyl)phenyl]oxazolidine-2,4-dione 
• 376641-08-6 ethyl (2E)-3-(2-fluoro-6-trifluoromethylphenyl)propenoate 
• 207981-50-8 2-hydroxy-2-(2,6-difluorophenyl)acetic acid 
• 251366-72-0 2-fluoro-6-trifluoromethylmandelic acid 
• 58914-35-5 2-hydroxy-6-(trifluoromethyl)benzaldehyde 
• 1186664-62-9 2-amino-4-(2-fluoro-6-(trifluoromethyl)phenyl)-6-phenylsulfanylpyridine-3,5-dicarbonitrile 

Relevant academic research and scientific papers

Method for preparing 2-fluoro-6-trifluoromethylbenzaldehyde by using continuous flow reaction device

The embodiment of the invention discloses a method for preparing 2-fluoro-6-trifluoromethylbenzaldehyde by using a continuous flow reaction device, and belongs to the technical field of pharmaceuticaland chemical synthesis. The method includes: reacting a

[...] and its sodium salt intermediate and its salt preparation method and application (by machine translation)

The invention application [...] and its sodium salt intermediate and its salt preparation method and application, relates to medical intermediate and its preparation method and application. The present invention provides a process content provided by the

PROCESSES TO PRODUCE ELAGOLIX

The present invention relates to a scalable process for the making of elagolix, its salts and the process of intermediate compounds.

Synthesis method of key raw material compound C of Elagolix

The invention relates to a synthesis method of a key raw material compound C of Elagolix. The synthesis method comprises the following steps: performing reaction of 3-flourine-trifluorotoluene, an organic lithium reagent and DMF in the presence of TMEDA a

Regioselective formylation of 1,3-disubstituted benzenes through in situ lithiation

A facile method of regioselective formylation of disubstituted benzene via in situ deprotonation/metalation using n-BuLi/TMEDA/DIPA has been developed. Effect of different electron withdrawing and electron donating substituents in 1,3-interrelated aromatic system was studied; the metalation mostly occurred at the 2-position to afford the desired products in high yields.

Fluorine as an ortho-directing group in aromatic metalation: A two step preparation of substituted benzo[b] thiophene-2-carboxylates

A simple 2-step synthesis of B-ring substituted benzo[b]thiophene-2-carboxylates from aryl fluorides has been developed. The route involves a selective lithiation ortho to fluorine, followed by formylation, and subsequently, displacement of fluorine with