1261269-66-2

Usage

Uses

Used in Chemical Synthesis:
2,4,6-trichloronicotinaldehyde is used as an intermediate in the synthesis of various organic compounds due to its reactive nature and the presence of chlorine atoms.
Used in Laboratory Experiments and Chemical Reactions:
2,4,6-trichloronicotinaldehyde is utilized as a reagent in laboratory experiments and chemical reactions, where its strong odor and reactivity are advantageous for specific applications.
Used in Pesticide and Insecticide Production:
2,4,6-trichloronicotinaldehyde is used as a key component in the production of insecticides and pesticides, leveraging its strong toxic properties to effectively control and eliminate pests.
Used in Industrial Applications:
Although not explicitly mentioned in the provided materials, 2,4,6-trichloronicotinaldehyde may also be used in other industrial applications where its chemical properties are beneficial, such as in the manufacturing of dyes, plastics, or pharmaceuticals.

Upstream product

• 16063-69-7 2,4,6-trichloropyridine 
• 107-31-3 Methyl formate 
• 109-94-4 formic acid ethyl ester 
• 2591-86-8 N-Formylpiperidine 

Downstream Products

• 1658467-36-7 4,6-dichloro-3-iodo-1H-pyrazolo[4,3-c]pyridine 
• 1347758-89-7 C₁₇H₂₄N₄O₂ 
• 1347758-88-6 6-chloro-4-(cyclohexyloxy)-3-methyl-1H-pyrazolo[4,3-c]pyridine 
• 1347758-87-5 C₁₃H₁₇ClN₄ 
• 120422-90-4 4,6-dichloro-3-methylpyrazolo<4,3-c>pyridine 
• 1347759-13-0 1-(2,4,6-trichloro-pyridin-3-yl)ethanone 
• 1256794-28-1 4,6-dichloro-3aH-pyrazolo[4,3-c]pyridine 

Relevant academic research and scientific papers

Modulators of STING (Stimulator of Interferon Genes)

Compounds of the general formula (I): or a pharmaceutically acceptable salt thereof, processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

Luminescent Mono-, Di-, and Triradicals: Bridging Polychlorinated Triarylmethyl Radicals by Triarylamines and Triarylboranes

Up to three polychlorinated pyridyldiphenylmethyl radicals bridged by a triphenylamine carrying electron withdrawing (CN), neutral (Me), or donating (OMe) groups were synthesized and analogous radicals bridged by tris(2,6-dimethylphenyl)borane were prepared for comparison. All compounds were as stable as common closed-shell organic compounds and showed significant fluorescence upon excitation. Electronic, magnetic, absorption, and emission properties were examined in detail, and experimental results were interpreted using DFT calculations. Oxidation potentials, absorption and emission energies could be tuned depending on the electron density of the bridges. The triphenylamine bridges mediated intramolecular weak antiferromagnetic interactions between the radical spins, and the energy difference between the high spin and low spin states was determined by temperature dependent ESR spectroscopy and DFT calculations. The fluorescent properties of all radicals were examined in detail and revealed no difference for high and low spin states which facilitates application of these dyes in two-photon absorption spectroscopy and OLED devices.

NOVEL NAPHTHYRIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ARRHYTHMIA

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; Wherein R1, R3-R6, X2 and X3 are as defined herein, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

PYRAZOLYL-SUBSTITUTED HETEROARYLS AND THEIR USE AS MEDICAMENTS

The invention relates to new substituted heteroaryls of formula 1 or of formula 1' wherein A is either N or CH, wherein R2 is selected from the group consisting of -C1-3-alkyl, -C1-3-haloalkyl, F, Br, CI, wherein Y is selected from -O- or -CH2-, and wherein R3 is defined as in claim 1, and the pharmaceutically acceptable salts thereof, and the use of these aforementioned compounds for the treatment of diseases such as asthma, COPD, allergic rhinitis, allergic dermatitis, lupus erythematodes, lupus nephritis and rheumatoid arthritis.

ALKYNYL ALCOHOLS AND METHODS OF USE

The invention relates to compounds of Formula (0): wherein A1-A8, R4 and R5 each has the meaning as described herein. Compounds of Formula (0) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over-activation of NF-kB signaling is observed.

ALKYNYL ALCOHOLS AND METHODS OF USE

The invention relates to compounds of Formula (0): wherein A1-A8, R4 and R5 each has the meaning as described herein. Compounds of Formula (0) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over-activation of NF-kB signaling is observed.

ALKYNYL ALCOHOLS AND METHODS OF USE

The invention relates to compounds of Formula (0): wherein Q, A1-A8, R4 and R5 and each has the meaning as described herein. Compounds of Formula (0) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over- activation of NF-kB signaling is observed.

PYRAZOLOPYRIDINES AS INHIBITORS OF THE KINASE LRRK2

A compound of formula la or formula lb, or a pharmaceutically acceptable salt or ester thereof, wherein R1 is selected from: aryl; heteroaryl; -NHR3; fused aryl-C4-7-heterocycloalkyl; - CONR4R5; -NHCO