1261422-97-2

Upstream product

• 159572-27-7 (R)-2-((benzyloxy)methoxy)propanal 
• 3587-60-8 Benzyloxymethyl chloride 
• 154674-77-8 2-Methylpropyl (R)-2-(benzyloxymethoxy)propanoate 
• 588728-59-0 (E)-methyl 5-bromo-2,2-dimethylpent-3-enoate 
• 76352-72-2 methyl 2,2-dimethyl-4-pentenoate 
• 1261422-95-0 (E)-(4S,6R,7R)-7-((benzyloxy)methoxy)-6-((4-methoxybenzyl)oxy)oct-1-en-4-yl 5-((tert-butyldimethylsilyl)oxy)-2,2-dimethylpent-3-enoate 
• 1261422-91-6 (E)-5-((tert-butyldimethylsilyl)oxy)-2,2-dimethylpent-3-enoic acid 
• 122520-56-3 (E)-methyl 5-((tert-butyldimethylsilyl)oxy)-2,2-dimethylpent-3-enoate 

Downstream Products

• 1261423-03-3 (2S,6S)-6-((2R,3R)-3-((benzyloxy)methoxy)-2-((4-methoxybenzyl)oxy)butyl)-2-((E)-5-((tert-butyldimethylsilyl)oxy)-2-methylpent-3-en-2-yl)-2-methoxydihydro-2H-pyran-3(4H)-one 
• 1261423-05-5 (E)-methyl 2-((2S,6S)-6-((2R,3R)-3-((benzyloxy)methoxy)-2-((4-methoxybenzyl)oxy)butyl)-2-((E)-5-((tert-butyldimethylsilyl)oxy)-2-methylpent-3-en-2-yl)-2-methoxy-3-oxodihydro-2H-pyran-4(3H)-ylidene)acetate 
• 1261423-07-7 (E)-methyl 2-((2S,3S,6S)-3-acetoxy-6-((2R,3R)-3-((benzyloxy)methoxy)-2-((4-methoxybenzyl)oxy)butyl)-2-((E)-5-((tert-butyldimethylsilyl)oxy)-2-methylpent-3-en-2-yl)-2-methoxydihydro-2H-pyran-4(3H)-ylidene)acetate 
• 1261423-32-8 (E)-methyl 2-((2S,3S,6S)-3-acetoxy-6-((2R,3R)-3-((benzyloxy)methoxy)-2-((4-methoxybenzyl)oxy)butyl)-2-((E)-5-hydroxy-2-methylpent-3-en-2-yl)-2-methoxydihydro-2H-pyran-4(3H)-ylidene)acetate 
• 1261423-09-9 (E)-methyl 2-((2S,3S,6S)-3-acetoxy-6-((2R,3R)-3-((benzyloxy)methoxy)-2-((4-methoxybenzyl)oxy)butyl)-2-methoxy-2-((E)-2-methyl-5-oxopent-3-en-2-yl)dihydro-2H-pyran-4(3H)-ylidene)acetate 
• 1261423-30-6 (E)-(4S,6R,7R)-7-((benzyloxy)methoxy)-6-((4-methoxybenzyl)oxy)-1-oxooctan-4-yl 5-((tert-butyldimethylsilyl)oxy)-2,2-dimethylpent-3-enoate 
• 1261422-99-4 (E)-(5S,7R,8R)-8-((benzyloxy)methoxy)-7-((4-methoxybenzyl)oxy)non-1-en-5-yl 5-((tert-butyldimethylsilyl)oxy)-2,2-dimethylpent-3-enoate 
• 1261423-01-1 (((E)-4-((S)-2-((2R,3R)-3-((benzyloxy)methoxy)-2-((4-methoxybenzyl)oxy)butyl)-3,4-dihydro-2H-pyran-6-yl)-4-methylpent-2-en-1-yl)oxy)(tert-butyl)dimethylsilane 

Relevant academic research and scientific papers

BRYOSTATIN ANALOGS AND USE THEREOF AS ANTIVIRAL AGENTS

Described herein are tricyclic macrolactones. The macrolactones have a high binding affinity for PKC. The compounds described herein can be used in a number of therapeutic applications including the treatment or prevention of viral infection. Also described herein are methods for producing macrolactones. The methods permit the high-yield synthesis of macrolactones in a low number of steps and with a high degree of substitution and specificity.

Total synthesis of bryostatin 1

Bryostatin 1 is a marine natural product that is a very promising lead compound because of the potent biological activity it displays against a variety of human disease states. We describe herein the first total synthesis of this agent. The synthetic rout