197895-07-1

Upstream product

• 126167-36-0 1-phenyl-6,7-dihydro[1,4]diazepino[6,7,1-hi]indole-3,4-dione 3-oxime 
• 27158-79-8 1-phenyl-6,7-dihydro-3H-[1,4]diazepino[6,7,1-hi]indol-4-one 
• 126149-54-0 (RS)-3-amino-5-phenyl-3,4,6,7,-tetrahydropyrrolo<3,2,1-jk><1,4>benzodiazepin-4(3H)-one 
• 126252-50-4 (3R)-3-amino-5-phenyl-3,4,6,7-tetrahydropyrrolo<3,2,1-jk><1,4>benzodiazepin-4(3H)-one 

Downstream Products

• 197895-10-6 (9-nitro-4-oxo-1-phenyl-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-3-yl)-carbamic acid tert-butyl ester 
• 197895-08-2 (R)-3,9-diamino-1-phenyl-6,7-dihydro-3H-[1,4]diazepino[6,7,1-hi]indol-4-one 
• 197895-13-9 (R)-3-amino-1-phenyl-9-pyrrolidin-1-yl-6,7-dihydro-3H-[1,4]diazepino[6,7,1-hi]indol-4-one 
• 197895-11-7 (9-amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-3-yl)-carbamic acid tert-butyl ester 
• 197894-84-1 (R)-N-[9-amino-3,4,6,7-tetrahydro-4-oxo-1-phenyl-pyrrolo[3.2.1-j,k][1,4]benzodiazepin-3-yl]-3-pyridinecarboxamide 
• 197895-12-8 (4-oxo-1-phenyl-9-pyrrolidin-1-yl-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-3-yl)-carbamic acid tert-butyl ester 
• 197894-77-2 (3R)-4-amino-N-(9-amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro[1,4]diazepino [6,7,1-hi]indol-3-yl)-3,5-dichlorobenzamide 
• 321527-83-7 (3R)-3-t-Butyloxycarbonylamino-N-(9-amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro [1,4 ]diazepino [6,7,1-hi]indol-3-yl) isonicotinamide 
• 197894-75-0 [4-((R)-9-amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro[1,4]diazepino[6,7,1-hi]indol-3-ylcarbamoyl)phenyl]carbamic acid tert-butyl ester 
• 319480-86-9 [2-((3R)-9-nitro-4-oxo-1-phenyl-3,4,6,7-tetrahydro[1,4]diazepino[6,7,1-hi]indol-3-ylcarbamoyl)phenyl]carbamic acid t-butyl ester 

Relevant academic research and scientific papers

Method for preparing substituted [1,4]diazepino[6,7,1-hi]indol-4-ones

Method for the preparation of enantiomerically pure diazepino-indolone of formula which comprises the intramolecular cyclization of a product of formula where A, B, X1, X2, Z, Z1, Z2and R are as defined in the d

Synthesis, structure-activity relationships, and pharmacological profile of 9-amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro[1,4]diazepino[6,7,1-hi]indoles: Discovery of potent, selective phosphodiesterase type 4 inhibitors

The synthesis, structure-activity relationships, and biological properties of a novel series of potent and selective phosphodiesterase type 4 (PDE4) inhibitors are described. These new aminodiazepinoindoles displayed in vitro PDE4 activity with submicromo