1261576-80-0

Basic information

• Product Name: C₃₀H₃₂ClN₃O₅S₂
• CAS NO: 1261576-80-0
• Molecular Weight: 614.186
• Mol File: 1261576-80-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₀H₃₂ClN₃O₅S₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₀H₃₂ClN₃O₅S₂(1261576-80-0)
• EPA Substance Registry System: C₃₀H₃₂ClN₃O₅S₂(1261576-80-0)

Safety Data

• Hazardous Substances Data: 1261576-80-0(Hazardous Substances Data)

Upstream product

• 198627-86-0 1,1-dimethylethyl 4-(3-hydroxyphenyl)-1-piperazinecarboxylate 
• 1261576-75-3 4,5-dichloro-N-(naphthalen-1-ylmethyl)thiophene-2-sulfonamide 

Relevant articles and documents

Microwave-assisted synthesis of 4-chloro-N-(naphthalen-1-ylmethyl)-5-(3- (piperazin-1-yl)phenoxy)thiophene-2-sulfonamide (B-355252): A new potentiator of nerve growth factor (NGF)-induced neurite outgrowth

The synthesis of 4-chloro-N-(naphthalen-1-ylmethyl)-5-(3-(piperazin-1-yl) phenoxy)thiophene-2-sulfonamide (B-355252) using an MW-assisted nucleophilic aromatic substitution (SNAr) reaction will be discussed. Utilization of this method allowed for the rapid generation of B-355252 heteroaryl ether core structure in the presence of cesium carbonate in dimethylformamide or tripotassium phosphate in N-methyl-2-pyrrolidone in 94% yield. Evaluation of B-355252 enhancement of nerve growth factor's ability to stimulate neurite outgrowths was determined using NS-1 cells.