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198627-86-0

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198627-86-0 Usage

General Description

1-(3-Hydroxy-phenyl)-piperazine-4-carboxylic acid tert-butyl ester is a chemical compound with the molecular formula C19H26N2O4. It is a tert-butyl ester derivative of piperazine-4-carboxylic acid, and it contains a hydroxyphenyl group. 1-(3-HYDROXY-PHENYL)-PIPERAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER is commonly used in pharmaceutical research and drug development as a building block in the synthesis of various biologically active compounds. It is also known for its potential pharmacological properties, including its ability to act as a central nervous system stimulant and its potential use in the treatment of certain psychiatric disorders. Furthermore, it has been studied for its potential anti-inflammatory and analgesic effects.

Check Digit Verification of cas no

The CAS Registry Mumber 198627-86-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,8,6,2 and 7 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 198627-86:
(8*1)+(7*9)+(6*8)+(5*6)+(4*2)+(3*7)+(2*8)+(1*6)=200
200 % 10 = 0
So 198627-86-0 is a valid CAS Registry Number.

198627-86-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-butyl 4-(3-hydroxyphenyl)piperazine-1-carboxylate

1.2 Other means of identification

Product number -
Other names N-boc-3-piperazin-1-yl-phenol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:198627-86-0 SDS

198627-86-0Relevant articles and documents

Structure-based optimisation of orally active & reversible MetAP-2 inhibitors maintaining a tight ‘molecular budget’

Hirst, David J.,Brandt, Martin,Bruton, Gordon,Christodoulou, Erica,Cutler, Leanne,Deeks, Nigel,Goodacre, Jonathan D.,Jack, Torquil,Lindon, Matthew,Miah, Afjal,Page, Kevin,Parr, Nigel,Shukla, Lena,Sims, Martin,Thomas, Pamela,Thorpe, James,Holmes, Duncan S.

supporting information, (2020/10/06)

Structure-based led optimisation of orally active reversible Methionine Aminopeptidase-2 (MetAP-2) inhibitors utilising a ‘molecular budget’ medicinal chemistry strategy is described. The key physicochemical parameters of target molecules (cLogP, molecula

PYRIDINE AMIDE DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS

-

Page/Page column 44, (2012/06/30)

The invention relates pyridine amide derivative of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are independently hydrogen, linear o branched (C1-C3)alkyl or joined together they form a cyclopropyl ring; R is independently selected from the group consisting of halogens and trifluoromethyl and p is 1, 2 or 3; A is C or N; E is a group of formula (B) or (C), wherein B is C(O)OH, C(O)O(C1-C3)alkyl, and C is selected from the group consisting of formula (I) m is 1,2 or 3, n is 0 or 1, W is -O-, -O(C1-C3 alkyl)-; -(C1-C3 alkyl)O-; -C(O)-; -C(=N-O(C1-C3 alkyl))-; -NH- or -NH(C1-C3alkyl)-; Ar is phenyl, optionally substituted with one or more substituents selected from the group consisting of halogen, trifluoromethyl, trifluoromethoxy, methyl, -NH(C1-C3alkyl)-; -N(C1-C3alkyl)(C1-C3alkyl)-, a from 5 to 7 membered heterocyclic ring containing one nitrogen atom which is convalently bonded to Ar and optionally containing one or two heteroatoms selected from N, O and S; and a 5- or 6-membered heteroaromatic ring containing 1 to 3 heteroatoms selected from S, O e N, such heteroaromatic ring being substituted with one or two substituents selected from the group consisting of (C1-C3)alkyl, (C3-C5)cycloalkyloxy, (C1-C3)alkylcarbonyl. The compounds of the invention could be used for manufacturing a medicament for the treatment of pathologies which require the use of an antagonist of the EP4 receptor, such as the treatment of acute and chronic pain, inflammatory pain, osteoarthritis, inflammation-associated disorder as arthritis, rheumatoid artrhritis, cancer, endometriosis and migraine.

Synthesis of novel WAY 100635 derivatives containing a norbornene group and radiofluorination of [18F]AH1.MZ as a serotonin 5-HT1A receptor antagonist for molecular imaging

Herth, Matthias M.,Kramer, Vasko,Roesch, Frank

experimental part, p. 201 - 207 (2010/06/14)

5-HT1A receptors are involved in a variety of psychiatric disorders and in vivo molecular imaging of the 5-HT1A status represents an important approach to analyze and treat these disorders. We report herein the synthesis of three new

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