1261775-99-8

Upstream product

• 105884-19-3 1-(2-bromo-5-chlorophenyl)ethan-1-one 

Downstream Products

• 1381927-39-4 1-[2-(5-bromo-2-chlorophenyl)-2-oxoethyl]pyridinium bromide 
• 1380796-81-5 2-(5-bromo-2-chlorophenyl)-5-methylpyridine 
• 1380796-86-0 1-[4-chloro-3-(5-methylpyridin-2-yl)-phenyl]piperidine-4-carboxylic acid ethyl ester 
• 1380796-87-1 1-[4-chloro-3-(5-methylpyridin-2-yl)phenyl]piperidine-4-carboxylic acid 
• 1380796-77-9 {1-[4-chloro-3-(5-methylpyridin-2-yl)-phenyl]piperidin-4-yl}-(4-methylpiperazin-1-yl)methanone 

Relevant academic research and scientific papers

COMPOUND FOR THE TREATMENT OF TUMOURS AND TUMOUR METASTASES

The invention relates to a Smoothened receptor ligand which antagonises the Hedgehog pathway, to pharmaceutical compositions and therapeutic applications thereof, processes for obtaining this compound and novel intermediates useful in these processes.

Development of a scalable route to the SMO receptor antagonist SEN794

A practical and scalable route to the SMO receptor antagonist SEN794 1 is described herein. A new and efficient access to the key intermediate 7 via the Kroehnke reaction was developed, significantly simplifying the synthesis and reducing costs. The optim