1380796-77-9

Upstream product

• 109-01-3 1-methyl-piperazine 
• 1380796-87-1 1-[4-chloro-3-(5-methylpyridin-2-yl)phenyl]piperidine-4-carboxylic acid 
• 74534-15-9 1-chloro-2-iodo-4-nitrobenzene 
• 105884-19-3 1-(2-bromo-5-chlorophenyl)ethan-1-one 
• 1190947-45-5 2-(2-chloro-5-nitro-phenyl)-5-methyl-pyridine 
• 6283-25-6 H₂NC₆H₃(Cl)NO₂ 
• 1380796-81-5 2-(5-bromo-2-chlorophenyl)-5-methylpyridine 
• 1380796-82-6 1-[2-(5-Bromo-2-chloro-phenyl)-2-oxo-ethyl]-pyridinium iodide 
• 1380796-86-0 1-[4-chloro-3-(5-methylpyridin-2-yl)-phenyl]piperidine-4-carboxylic acid ethyl ester 
• 1380796-80-4 4-chloro-3-(5-methyl-pyridin-2-yl)-phenylamine 
• 1261775-99-8 2-bromo-1-(5-bromo-2-chlorophenyl)ethanone 
• 1381927-39-4 1-[2-(5-bromo-2-chlorophenyl)-2-oxoethyl]pyridinium bromide 
• 1126-09-6 4-carbethoxypiperidine 

Relevant academic research and scientific papers

Compound for the treatment of tumours and tumour metastases

The invention relates to a Smoothened receptor ligand which antagonises the Hedgehog pathway, to pharmaceutical compositions and therapeutic applications thereof, processes for obtaining this compound and novel intermediates useful in these processes.

COMPOUND FOR THE TREATMENT OF TUMOURS AND TUMOUR METASTASES

The invention relates to a Smoothened receptor ligand which antagonises the Hedgehog pathway, to pharmaceutical compositions and therapeutic applications thereof, processes for obtaining this compound and novel intermediates useful in these processes.

Development of a scalable route to the SMO receptor antagonist SEN794

A practical and scalable route to the SMO receptor antagonist SEN794 1 is described herein. A new and efficient access to the key intermediate 7 via the Kroehnke reaction was developed, significantly simplifying the synthesis and reducing costs. The optim