126181-58-6

Upstream product

• 82845-20-3 [(diethoxyphosphoryl)difluoromethyl]zinc bromide 
• 624-65-7 2-propynyl chloride 
• 80084-30-6 (diethylphosphono)difluoromethyl cadmium bromide 
• 106-96-7 propargyl bromide 

Downstream Products

• 1225194-29-5 9-[4',4'-difluoro-4'-(diethylphosphono)but-1'-ynyl]-2-N-(N,N-dimethylaminomethylidene)-7-N-(2-nitrophenyl)sulfonyl-1N-(pivaloyloxy)methyl-9-deazaguanine 
• 948043-30-9 C₂₉H₃₅F₂N₆O₁₀PS 

Relevant academic research and scientific papers

FLUORINE IN ENZYME CHEMISTRY: PART 1. SYNTHESIS OF DIFLUOROMETHYLENEPHOSPHONATE DERIVATIVES AS PHOSPHATE MIMICS

Diethyl difluoromethylphosphonylcadmium bromide reacts with allyl and benzyl halides in THF to give the corresponding difluoromethylenephosphonate derivatives.The reaction with allyl bromide affords a versatile synthetic intermediate which undergoes a variety of synthetic transformations and therefore becomes a key compound in the preparation of elaborated difluoromethylenephosphonates of biological significance.

Allylations of zinc Bromide as a Convenient Route to 1,1-Difluoro-3-alkenephosphonates

The reaction of zinc bromide, (EtO)2P(O)CF2ZnBr, with allylic halides was found to be catalyzed by CuBr and represents a synthetically viable and convenient route to the title phosphonates.However, the reaction could no