1261818-69-2Relevant academic research and scientific papers
Compound with PDE4 inhibitory activity, preparation method, composition and application thereof
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Paragraph 0083, (2020/11/25)
The invention belongs to the field of medicines, and particularly relates to a compound with PDE4 inhibitory activity, and a preparation method, composition and application thereof. The compound is acompound with a structure shown as a formula I or pharmaceutically acceptable salt thereof, in the formula, R1 represents N, N-dimethylaminoethyl, 3-amino-3-oxopropyl, 3, 3-difluoropropyl and methoxyalkyl, and R2 represents a cyano group, an aminosulfonyl group, an aminocarbonyl group or an alkyl acylamino group. The compound provided by the invention has good PDE4 inhibitory activity, has the advantages of high efficiency and low side effect, and can be used for preparing drugs for preventing and/or treating allergic diseases, autoimmune diseases or inflammatory diseases.
