1262015-14-4

Upstream product

• 530-62-1 1,1'-carbonyldiimidazole 
• 302348-51-2 (4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol 
• 873-75-6 4-bromobenzenemethanol 
• 73183-34-3 bis(pinacol)diborane 
• 59016-93-2 p-hydroxymethylphenylboronic acid 
• 76-09-5 2,3-dimethyl-2,3-butane diol 
• 288-32-4 1H-imidazole 
• 1334019-92-9 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyloxycarbonyl chloride 
• 32315-10-9 bis(trichloromethyl) carbonate 

Relevant academic research and scientific papers

Tetrapod Polymersomes

Hollow nanoparticles such as polymersomes have promising potentials in many fields. However, the design and construction of higher-order polymersomes with precisely controlled spatial compartments is still very challenging. Herein, we report a unique tetr

ROS-responsive cyclodextrin nanoplatform for combined photodynamic therapy and chemotherapy of cancer

Cyclodextrin (CD) has special spatial structure and well biological safety, so it has been widely used for constructing CD-based nanoplatforms. Through functionalization, cyclodextrin can form various stimulus-response nanoplatforms, such as pH, temperatu

Hydrogen peroxide-Triggered gene silencing in mammalian cells through boronated antisense oligonucleotides

Hydrogen peroxide (H2O2) is a reactive oxygen species (ROS) involved in various diseases, including neurodegeneration, diabetes, and cancer. Here, we introduce a new approach to use H2O2 to modulate specific gene expression in mammalian cells. H2O2-responsive nucleoside analogues, in which the Watson-Crick faces of the nucleobases are caged by arylboronate moieties, were synthesized. One of these analogues, boronated thymidine (dTB), was incorporated into oligodeoxynucleotides (ODNs) using an automated DNA synthesizer. The hybridization ability of this boronated ODN to complementary RNA was clearly switched in the off-To-on direction upon H2O2 addition. Furthermore, we demonstrated H2O2-Triggered gene silencing in mammalian cells using antisense oligonucleotides (ASOs) modified with dTB. Our approach can be used for the regulation of any gene of interest by the sequence design of boronated ASOs and will contribute to the development of targeted disease therapeutics.

A boronate-caged [18F]FLT probe for hydrogen peroxide detection using positron emission tomography

Reactive oxygen species (ROS) play important roles in the development and progression of cancer and other diseases, motivating the development of translatable technologies for biological ROS imaging. Here we report Peroxy-Caged-[18F]Fluorodeoxy

A biocompatible oxidation-triggered carrier polymer with potential in therapeutics

Dextran, a water-soluble, biocompatible polymer of glucose, was modified at its hydroxyls with arylboronic esters to make it soluble in common organic solvents, allowing for the facile preparation of oxidation-sensitive dextran (Oxi-DEX) carrier micropart

A glucose-depleting silica nanosystem for increasing reactive oxygen species and scavenging glutathione in cancer therapy

Cancer cells adapt to cellular oxidative stress by increasing glutathione (GSH). An organically modified silica nanosystem (ORMOSIL@GOx) was fabricated to achieve a lethal level of oxidative stress in cancer cells by depleting intracellular GSH while incr

High Drug Loading and Sub-Quantitative Loading Efficiency of Polymeric Micelles Driven by Donor-Receptor Coordination Interactions

Polymeric micelles are extensively used for the delivery of hydrophobic drugs, which, however, suffer from unsatisfactory drug loading, colloidal uniformity, formulation stability, and drug release. Herein, we demonstrate a convenient strategy to prepare micelles with ultrahigh drug loading via the incorporation of polymer-drug coordination interactions. An amphiphilic copolymer containing pendant phenylboronic acid as electron acceptor unit was synthesized, which afforded donor-acceptor coordination with doxorubicin to obtain micelles with ultrahigh drug loading (～50%), nearly quantitative loading efficiency (>95%), uniform size, and colloidal stability. Besides, the encapsulated drug can be effectively and selectively released in response to the high reactive oxygen species levels in cancer cells, which potentiated the anticancer efficacy and reduced systemic toxicity. Apart from doxorubicin, the current platform could be extended to other drugs with electron-donating groups (e.g., epirubicin and irinotecan), rendering a simple and robust strategy for enabling high drug loading in polymeric micelles and cancer-specific drug release.

Active oxygen responsive antioxidant nitric oxide donor, and preparation method and application thereof

The invention relates to the field of medicinal chemistry, and especially relates to an active oxygen responsive antioxidant nitric oxide donor, and a preparation method and application thereof. The donor has a structural formula shown in the specification. The preparation method comprises the following steps: reacting PBAP with CDI to obtain PBAP-CDI; and reacting with ISN under the action of a catalyst to obtain the antioxidant nitric oxide donor. The active oxygen responsive antioxidant nitric oxide donor disclosed by the invention is good in stability and long in half-life period in a physiological environment, can be decomposed and released only under the stimulation of high-concentration active oxygen in inflammatory tissues, and does not generate side effects on normal tissues. Meanwhile, active oxygen can be effectively removed, and the anti-oxidation effect is achieved; and the antioxidant nitric oxide donor can promote the growth of endothelial cells and inhibit the growth of smooth muscle cells, is beneficial to rapid endothelialization of heart and blood vessels, has diversified functions, can be widely applied to drug development, and has popularization and application values.

3' PROTECTED NUCLEOTIDES

The present disclosure provides 3' protected nucleotides, including those 3' protected nucleotides having a detectable tag. Systems and methods of sequencing nucleic acids using the 3' protected nucleotides are also disclosed, such as the sequencing of a nucleic acid using a nanopore or the sequencing of a nucleic acid via sequencing-by-synthesis.

Multiple-target-point treating micelle for regulating and controlling microenvironment of Alzheimer disease (AD) and preparation method of multiple-target-point treating micelle

The invention belongs to the field of drug preparations, and relates to a multiple-target-point treating micelle for regulating and controlling the microenvironment of Alzheimer disease (AD) and a preparation method of the multiple-target-point treating m