1262046-34-3

Basic information

• Product Name: Rockphos
• Synonyms: Rockphos;2-Di-tert-butylphosphino-3-Methoxy-6-Methyl-2'-4'-6'-triisopropylbiphenyl, 98% Min;2-(Di-t-butylphosphino)-3-Methoxy-6-Methyl-2'-4'-6'-tri-i-propyl-1,1'-biphenyl, Min. 98% RockPhos;Bis(1,1-dimethylethyl)[3-methoxy-6-methyl-2',4',6'-tris(1-methylethyl)[1,1'-biphenyl]-2-yl]phosphine;2-Di-tert-butylphosphino-3-Methoxy-6-Methyl-2',4',6'-triisopropyl-1,1'-biphenyl;2-Di(tert-butyl)phosphino-2′,4′,6′-triisopropyl-3-methoxy-6-methylbiphenyl;Di-tert-butyl(2′,4′,6′-triisopropyl-3-methoxy-6-methyl-[1,1′-biphenyl]-2-yl)phosphine;RockPhos 97%
• CAS NO: 1262046-34-3
• Molecular Formula: C₃₁H₄₉OP
• Molecular Weight: 468.693921
• EINECS: -0
• Product Categories: Achiral Phosphine;Aryl Phosphine;Buchwald Ligands Series;Buchwald Ligands&Precatalysts
• Mol File: 1262046-34-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 129-130°C
• Boiling Point: 526.6±50.0 °C(Predicted)
• Appearance: white/crystal
• Storage Temp.: 15-25°C
• CAS DataBase Reference: Rockphos(CAS DataBase Reference)
• NIST Chemistry Reference: Rockphos(1262046-34-3)
• EPA Substance Registry System: Rockphos(1262046-34-3)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 1262046-34-3(Hazardous Substances Data)

Usage

Reaction

Ligand used in the palladium-catalyzed C-O bond forming reactions of secondary and primary alcohols with a range of aryl halides. Heterocyclic halides and, for the first time, electron-rich aryl halides can be coupled with secondary alcohols.

Uses

Different sources of media describe the Uses of 1262046-34-3 differently. You can refer to the following data:
1. Rockpahos is commonly used as a catalyst in organic reactions along with a palladium compound catalyst.
2. RockPhos is a biphenyl-based phosphine ligand used with Pd(0) catalyst for carbon-carbon and carbon-heteroatom bond formation reactions.It can also be employed in the: 2-fluroethoxylation of bromo-chalcones in the presence of palladium catalyst.Conversion of aryl chlorides into aryl methoxides using RockPhos Pd G3 as a catalyst.

Upstream product

• 13716-10-4 di(tert-butyl)chlorophosphine 
• 1351403-03-6 2-iodo-2',4',6'-triisopropyl-3-methoxy-6-methyl-1,1'-biphenyl 
• 452-78-8 3-fluoro-4-methyl phenol 
• 21524-34-5 2,4,6-triisopropyl-1-bromobenzene 
• 405-06-1 2-fluoro-4-methoxy-1-methylbenzene 
• 108894-99-1 (2,4,6-triisopropylphenyl)magnesium bromide 
• 108-86-1 bromobenzene 
• 1402393-57-0 2-bromo-2',4',6'-triisopropyl-3-methoxy-6-methylbiphenyl 

Downstream Products

• 1345093-36-8 PdFC₆H₄(CH₂)3CH₃C₆H₂(CH(CH₃)2)3C₆H₂OCH₃CH₃P(C(CH₃)3)2 
• 1345093-35-7 PdBrC₆H₄(CH₂)3CH₃C₆H₂(CH(CH₃)2)3C₆H₂OCH₃CH₃P(C(CH₃)3)2 

Relevant articles and documents

Pd-Catalyzed Etherification of Nitroarenes

The Pd-catalyzed etherification of nitroarenes with arenols has been achieved using a new rationally designed ligand. Mechanistic insights were used to design the ligand so that both the oxidative addition and reductive elimination steps of a plausible catalytic cycle were facilitated. The catalytic system established here provides direct access to a range of unsymmetrical diaryl ethers from nitroarenes.

A single phosphine ligand allows palladium-catalyzed intermolecular C-O bond formation with secondary and primary alcohols

Forging a bond: An efficient, general palladium catalyst for C-O bond-forming reactions of secondary and primary alcohols with a range of aryl halides has been developed using the ligand 1. Heteroaryl halides, and for the first time, electron-rich aryl halides can be coupled with secondary alcohols. A diverse set of substrate combinations are possible with just a single ligand, thus obviating the need to survey multiple ligands. Copyright