1262097-65-3Relevant academic research and scientific papers
Sequential enantiodivergent organocatalysis: Reversibility in enantioswitching controlled by a conformationally flexible guanidine/bisthiourea organocatalyst
Sohtome, Yoshihiro,Yamaguchi, Takahisa,Tanaka, Shinji,Nagasawa, Kazuo
supporting information, p. 2780 - 2786 (2013/05/09)
Here we describe our studies on solvent-dependent enantiodivergent Mannich-type reactions utilizing conformationally flexible guanidine/bisthiourea organocatalyst (S,S)-1. Our mechanistic investigations revealed that the stereo-determining steps in both t
Solvent-dependent enantiodivergent mannich-type reaction: Utilizing a conformationally flexible guanidine/bisthiourea organocatalyst
Sohtome, Yoshihiro,Tanaka, Shinji,Takada, Keisuke,Yamaguchi, Takahisa,Nagasawa, Kazuo
supporting information; experimental part, p. 9254 - 9257 (2011/02/22)
Flex control: Malonate and tert-butoxycarbonyl (Boc)-protected imines react in the presence of the flexible catalyst 1 to furnish the S or the R adduct depending upon the solvent used. Kinetic analyses in this enantiodivergent organocatalysis show that en
