1262282-71-2Relevant academic research and scientific papers
Copper(II)chloride-mediated cyclization reaction of N-alkoxy- orthoalkynylbenzamides
Jithunsa, Manita,Ueda, Masafumi,Miyata, Okiko
, p. 518 - 521 (2011/04/16)
A regioselective intramolecular cyclization/halogenation reaction of N-alkoxy-o-alkynylbenzamides with CuCl2/NCS was developed. The corresponding 3-(chloromethylene)isobenzofuran-1-ones were exclusively obtained via 5-exo-dig cyclization in moderate to excellent yields within 0.5-1 h. This approach has been successfully used to synthesize a biaryl compound by the Suzuki-Miyaura reaction.
