1262283-71-5Relevant academic research and scientific papers
Transition-metal-free synthesis of benzimidazoles mediated by KOH/DMSO
Baars, Hannah,Beyer, Astrid,Kohlhepp, Stefanie V.,Bolm, Carsten
supporting information, p. 536 - 539 (2014/04/03)
Benzimidazoles are prepared by intramolecular N-arylations of amidines mediated by potassium hydroxide in DMSO at 120 °C. In this manner, diversely substituted products have been obtained in moderate to very good yields.
Synthesis of annulated benzimidazoles via amidine cyclization
Liubchak, Kostiantyn,Nazarenko, Kostiantyn,Tolmachev, Andrey
experimental part, p. 2993 - 3000 (2012/05/31)
Structurally diverse annulated benzimidazoles were synthesized via two copper(I)-catalyzed cyclocondensation reactions. In the first case the title compounds were prepared from lactams and o-bromoaniline. An alternative route consisted of an intramolecular cyclization of o-bromoarylamidines.
Ligand-free copper-catalyzed synthesis of substituted benzimidazoles, 2-aminobenzimidazoles, 2-aminobenzothiazoles, and benzoxazoles
Saha, Prasenjit,Ramana, Tamminana,Purkait, Nibadita,Ali, Md. Ashif,Paul, Rajesh,Punniyamurthy, Tharmalingam
body text, p. 8719 - 8725 (2010/02/28)
(Chemical Equation Presented) The synthesis of substituted benzimidazoles, 2-aminobenzimidazoles, 2-aminobenzothiazoles, and benzoxazoles is described via intramolecular cyclization of o-bromoaryl derivatives using copper(II) oxide nanoparticles in DMSO under air. The procedure is experimentally simple, general, efficient, and free from addition of external chelating ligands. It is a heterogeneous process and the copper(II) oxide nanoparticles can be recovered and recycled without loss of activity. 2009 American Chemical Society.
