1262446-50-3

Upstream product

• 1262446-43-4 2-amino-5-carbamoyl-3-p-tolylpyrimidin-4(3H)-one 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 1262446-62-7 3-carbamoyl-7-methoxy-1-p-tolyl-1H-pyrimido[1,2-a]pyrimidine-2,6-dione 
• 1262446-60-5 3-carbamoyl-7-methoxycarbonyl-1-p-tolyl-1H-pyrimido[1,2-a]pyrimidine-2,6-dione 
• 1262446-61-6 3-carbamoyl-1-p-tolyl-1H-pyrimido[1,2-a]pyrimidine-2,6-dione 

Relevant academic research and scientific papers

Synthesis of nitrogen bicyclic scaffolds: Pyrimido[1,2-a]pyrimidine-2,6- diones

The multi-step synthesis of 1,3,7-trisubstituted pyrimido[1,2-a] pyrimidinediones starting from isothiocyanates is described. These nitrogen bicycles were prepared by an iterative sequence of functionalization/ cyclocondensation reactions. [4+2] Cycloaddition reactions took place between diazadienic chains and various acyl chlorides providing sophisticated heterobicycles.