1262486-29-2

Upstream product

• 1262486-26-9 1-(4-methoxybenzyl)-5-chloro-3-ethoxy-6-isobutylpyrazin-2(1H)-one 
• 849775-01-5 1-(4-methoxybenzyl)-3,5-dichloro-6-isobutylpyrazin-2(1H)-one 

Downstream Products

• 1262486-32-7 2-(4-methoxybenzylthio)-5-chloro-3-ethoxy-6-isobutylpyrazine 
• 1262486-41-8 2-chloro-6-ethoxy-3-isobutyl-5-(3,4-dimethoxyphenyl)pyrazine 
• 1262486-42-9 2-chloro-6-ethoxy-5-(3,4-difluorophenyl)-3-isobutylpyrazine 
• 1262486-47-4 2-ethoxy-6-ethynyl-5-isobutyl-3-(3,4-dimethoxyphenyl)pyrazine 
• 1262486-54-3 (2R,3R,4R,5R)-2-(benzoyloxymethyl)-5-(4-(5-(3,4-dimethoxyphenyl)-6-ethoxy-3-isobutylpyrazin-2-yl)-1H-1,2,3-triazol-1-yl)tetrahydrofuran-3,4-diyl dibenzoate 
• 1262486-55-4 ((2R,3S,5R)-3-(4-chlorobenzoyloxy)-5-(4-(5-(3,4-dimethoxyphenyl)-6-ethoxy-3-isobutylpyrazin-2-yl)-1H-1,2,3-triazol-1-yl)tetrahydrofuran-2-yl)methyl 4-chlorobenzoate 
• 1262486-56-5 2-(1-benzyl-1H-1,2,3-triazol-4-yl)-6-ethoxy-3-isobutyl-5-(3,4-dimethoxyphenyl)pyrazine 
• 1262486-57-6 2-ethoxy-5-isobutyl-3-(3,4-dimethoxyphenyl)-6-(1H-1,2,3-triazol-4-yl)pyrazine 

Relevant academic research and scientific papers

Efficient preparation of tetrasubstituted pyrazines starting from pyrazin-2(1H)-ones

An efficient methodology for the synthesis of tetrasubstituted pyrazines starting from pyrazin-2(1H)-ones has been elaborated. Diversity in the functionalization and the beneficial effect of microwave irradiation throughout the methodology has been demonstrated. Georg Thieme Verlag Stuttgart · New York.

An expeditious route toward pyrazine-containing nucleoside analogues

An improved and convenient methodology for the synthesis of asymmetrically substituted pyrazines starting from 3,5-dichloropyrazin-2(1H)-ones has been elaborated. Several nucleoside analogues have been synthesized containing the pyrazine core as the organic base coupled with the sugar via a triazole linkage. The beneficial effect of microwave irradiation throughout the sequence has been demonstrated.