126251-10-3

Basic information

• Product Name: H-D-Phe-L-Pro-OMe
• Synonyms: H-D-Phe-L-Pro-OMe
• CAS NO: 126251-10-3
• Molecular Weight: 276.335
• Mol File: 126251-10-3.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: H-D-Phe-L-Pro-OMe(CAS DataBase Reference)
• NIST Chemistry Reference: H-D-Phe-L-Pro-OMe(126251-10-3)
• EPA Substance Registry System: H-D-Phe-L-Pro-OMe(126251-10-3)

Safety Data

• Hazardous Substances Data: 126251-10-3(Hazardous Substances Data)

Upstream product

• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 2133-40-6 L-proline methyl ester monohydrochloride 
• 147-85-3 L-proline 
• 18942-49-9 Boc-D-Phe-OH 
• 2577-48-2 methyl (2S)-pyrrolidine carboxylate 
• 126251-09-0 Boc-D-Phe-L-Pro-OMe 
• 38017-89-9 t-butyloxycarbonyl-L-phenylalanyl-L-proline methyl ester 

Downstream Products

• 95311-05-0 anthranoyl dipeptide methyl ester 
• 95311-06-1 (S)-1-[(S)-2-(2-Methylamino-benzoylamino)-3-phenyl-propionyl]-pyrrolidine-2-carboxylic acid methyl ester 
• 442682-29-3 methyl (S)-1-[(S)-2-(2-{(S)-1-[(S)-2-tert-butoxycarbonylamino-3-phenylpropanoyl]pyrrolidin-2-yl}thiazol-4-ylcarbonylamino)-3-phenylpropanoyl]pyrrolidine-3-carboxylate 
• 914771-44-1 (3S,8aS)-3-benzyloctahydropyrrolo[1,2-a]pyrazine 
• 1374558-54-9 N,N-dibenzyl-L-phenylalanyl-L-proline methyl ester 
• 1374558-52-7 N,N-dibenzyl-D-phenylalanyl-L-proline methyl ester 
• 1415034-06-8 C₂₃H₃₃N₃O₆ 
• 1446424-88-9 calcaripeptide B 

Relevant articles and documents

Synthesis, characterization and antimicrobial activity of protected dipeptides and their deprotected analogs

Peptides are the chemical compounds which consist of amino acids coupled together by peptide linkage. Peptide derivatives are synthesized by coupling the carboxyl group of one amino acid with amino group of other. Due to the possibilities of fortuitous and unintentional reactions, various protecting groups are used to protect the carboxylic acid as well as amino groups of both the amino acids. These peptide derivatives are associated with a variety of pharmacological activities including antibacterial and antifungal activities. While doing our analysis some of the dipeptides were synthesized in a reasonable yield and purity which were fully characterised by FTIR and H1 NMR. The antimicrobial activity of these derivatives was studied and these were found to be active against two strains of fungi (Aspergillus fumigatus & Pencillium chrysogenum) and two strains of bacteria (E. coli and Salmonella typhimurium). This provides for a future insight to work on the synthesis of these dipeptide derivatives to achieve their stability.

Stereoselective total synthesis of marine cyclodepsipeptide calcaripeptides A-C

The first stereoselective total syntheses of marine cyclodepsipeptides, calcaripeptides A-C, have been accomplished. Emphasis was given particularly in identification of an efficient strategy for the macrocyclization. The notable features of our synthesis include Evans alkylation, Crimmins syn-aldol, Crimmins acetate aldol, Wittig olefination, and Shiina macrolactonization reactions. An anomaly in the 1H NMR of the proposed calcaripeptide B has been amended during this synthetic study. (Chemical Equation Presented).

Cyanobacterial peptides as a prototype for the design of potent β-secretase inhibitors and the development of selective chemical probes for other aspartic proteases

Inspired by marine cyanobacterial natural products, we synthesized modified peptides with a central statine-core unit, characteristic for aspartic protease inhibition. A series of tasiamide B analogues inhibited BACE1, a therapeutic target in Alzheimer's