1262521-81-2

Basic information

• Product Name: 6-methoxy-1H-benzo[d][1,2,3]triazol-1-yl benzoate
• Synonyms: 6-methoxy-1H-benzo[d][1,2,3]triazol-1-yl benzoate
• CAS NO: 1262521-81-2
• Molecular Weight: 269.26
• Mol File: 1262521-81-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-methoxy-1H-benzo[d][1,2,3]triazol-1-yl benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: 6-methoxy-1H-benzo[d][1,2,3]triazol-1-yl benzoate(1262521-81-2)
• EPA Substance Registry System: 6-methoxy-1H-benzo[d][1,2,3]triazol-1-yl benzoate(1262521-81-2)

Safety Data

• Hazardous Substances Data: 1262521-81-2(Hazardous Substances Data)

Upstream product

• 65-85-0 benzoic acid 
• 26198-31-2 6-methoxy-1H-benzo[d][1,2,3]triazol-1-ol 

Relevant articles and documents

Discovery of 1H-benzo[d][1,2,3]triazol-1-yl 3,4,5-trimethoxybenzoate as a potential antiproliferative agent by inhibiting histone deacetylase

Twenty-one benzotriazoles (3-16 and 18-24) were synthesized and half of them (5, 8-16, 20, and 21) were reported for the first time. Their antiproliferative activities against three human cancer cells were assayed. It revealed that 1H-benzo[d][1,2,3]triazol-1-yl 3,4,5-trimethoxybenzoate (9) showed considerable activity against three human cancer cell lines with the half maximal inhibitory concentration (IC50) values of 1.2-2.4 nM, which were close to the value of the positive control, doxorubicin. Further investigation indicated compound 9 was a potential histone deacetylase inhibitor (IC50 = 9.4 μM) and its binding mode was simulated using docking method.