126267-43-4

Basic information

• Product Name: 2-Propen-1-one, 3-(4-chlorophenyl)-1-(2-hydroxy-5-methylphenyl)-, (E)-
• CAS NO: 126267-43-4
• Molecular Formula: C16H13ClO2
• Molecular Weight: 272.731
• Mol File: 126267-43-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-Propen-1-one, 3-(4-chlorophenyl)-1-(2-hydroxy-5-methylphenyl)-, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propen-1-one, 3-(4-chlorophenyl)-1-(2-hydroxy-5-methylphenyl)-, (E)-(126267-43-4)
• EPA Substance Registry System: 2-Propen-1-one, 3-(4-chlorophenyl)-1-(2-hydroxy-5-methylphenyl)-, (E)-(126267-43-4)

Safety Data

• Hazardous Substances Data: 126267-43-4(Hazardous Substances Data)

Upstream product

• 1450-72-2 5-methyl-2-hydroxyacetophenone 
• 104-88-1 4-chlorobenzaldehyde 
• 75227-44-0 2'-Hydroxy-5'-methyl-4-chlorochalkone α,β-dibromide 

Downstream Products

• 139006-36-3 (2S,3R)-2-(4-Chloro-phenyl)-4,4-dimethoxy-6-methyl-chroman-3-ol 
• 60402-30-4 2-(4-chlorophenyl)-6-methyl-4H-chromen-4-one 
• 139006-44-3 (2R,3S)-2-(4-Chloro-phenyl)-3-hydroxy-6-methyl-chroman-4-one 
• 86691-09-0 2-[5-(4-Chloro-phenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-4-methyl-phenol 
• 75201-02-4 2-[5-(4-Chloro-phenyl)-4,5-dihydro-1H-pyrazol-3-yl]-4-methyl-phenol 

Relevant articles and documents

COMPOSITION FOR PROTECTING KIDNEY CONTAINING CHALCONE DERIVATIVES

The present invention relates to a composition for protecting a kidney or a composition for alleviating kidney diseases which contains a chalcone derivative. When the compound according to the present invention is used, the kidney can be protected from nephrotoxicity due to drugs and the like. Therefore, by utilizing the present specification, it is possible to make a great contribution to fields of patient treatment and welfare.COPYRIGHT KIPO 2019

Synthesis and fungicidal evaluation of novel chalcone-based strobilurin analogues

Strobilurin derivatives have become one of the most important classes of agricultural fungicide due to a novel action mode, wide fungicidal spectrum, lower toxicity toward mammalian cells, and environmentally benign characteristics. To discover new strobilurin analogues with high activity against resistant pathogens, a series of new chalcone-based strobilurin derivatives are designed and synthesized by integrating a chalcone scaffold with a strobilurin pharmacophore. The preliminary bioassay showed that some of the chalcone analogues exhibited good in vivo fungicidal activities against Pseudoperoniospora cubensis and Sphaerotheca fuliginea at the dosage of 200 μg mL-1. Two compounds, (￡)-methyl 2-[2-({3-[(￡)-3-(2- chlorophenyl)acryloyl]phenoxy}methyl)phenyl]-3-meth-oxyacrylate (1e) and (E)-methyl 2-[2-({3-[(E)-3-(3-bromophenyl)acryloyl]phenoxy}methyl)phenyl]-3- methoxyacrylate (11), were found to display higher fungicidal activities against P. cubensis (EC90 = 118.52 μg ml-1 for 1e and EC 90 = 113.64 μg mL-1 for 11) than Kresoxim-methyl (EC90 = 154.92 μg mL-1) and were identified as the most promising candidates for further study. The present work demonstrated that strobilurin analogues containing chalcone as a side chain could be used as a lead structure for further developing novel fungicides. To our knowledge, this is the first report about the syntheses and fungicidal activities of chalcone-based strobilurin derivatives.

Reaction of 2'-Hydroxychalcone Dibromides with Me2SO

2'-Hydroxychalcone dibromides on treatment with Me2SO gave 2'-hydroxychalcone, 2'-hydroxy-3'- or 2'-hydroxy-5'-bromochalcone, flavone, monobrominated flavone, 6,8-dibromoflavone, 3-bromoflavone, and 3-, 6-, or 8-dibromoflavone.