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12627-35-9

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  • 7,8-(Epoxymethano)-2H,6H-cyclobuta[5,6]benz[1,2-e]oxireno[4',4'a]-1-benzopyrano[5',6':6,7]indeno[1,2-b]indole-3,4b,7d(5H,7H)-triol,12-chloro-3,3a,6a,8,9,9a,10,11,14,14b,14c,15,16,16a-tetradecahydro-14

    Cas No: 12627-35-9

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  • 7,8-(Epoxymethano)-2H,6H-cyclobuta[5,6]benz[1,2-e]oxireno[4',4'a]-1-benzopyrano[5',6':6,7]indeno[1,2-b]indole-3,4b,7d(5H,7H)-triol,12-chloro-3,3a,6a,8,9,9a,10,11,14,14b,14c,15,16,16a-tetradecahydro-14

    Cas No: 12627-35-9

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  • 7,8-(Epoxymethano)-2H,6H-cyclobuta[5,6]benz[1,2-e]oxireno[4',4'a]-1-benzopyrano[5',6':6,7]indeno[1,2-b]indole-3,4b,7d(5H,7H)-triol,12-chloro-3,3a,6a,8,9,9a,10,11,14,14b,14c,15,16,16a-tetradecahydro-14

    Cas No: 12627-35-9

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  • 7,8-(Epoxymethano)-2H,6H-cyclobuta[5,6]benz[1,2-e]oxireno[4',4'a]-1-benzopyrano[5',6':6,7]indeno[1,2-b]indole-3,4b,7d(5H,7H)-triol,12-chloro-3,3a,6a,8,9,9a,10,11,14,14b,14c,15,16,16a-tetradecahydro-14

    Cas No: 12627-35-9

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12627-35-9 Usage

Description

Penitrem A is a tremorgenic mycotoxin, a toxic substance produced by certain fungi, specifically Penicillium species. It is a selective, irreversible blocker of the smooth muscle high conductance Ca2+-activated K+ (BK, KCa1.1) channel, which plays a significant role in vascular function and neuronal signaling. Penitrem A displays neurotoxicity in rats, causing convulsions and death in a dose-dependent manner. It forms colorless crystals when extracted from ethanol.

Uses

Used in Neurophysiological Research:
Penitrem A is used as a Ca2+-Activated K+ (BK) channel blocker to study its effect on BK current in bag cell neurons. This application helps researchers understand the role of BK channels in neuronal signaling and their potential involvement in various neurological conditions.
Used in Vascular Function Studies:
As an important tool for studying the role of BK channels in vascular function, Penitrem A is effective in cellular, tissue, and in vivo experiments. It helps researchers explore the mechanisms of blood vessel regulation and the potential therapeutic targets for cardiovascular diseases.
Used in Ion Channel Research:
Penitrem A is used to inhibit BK channels in inside-out and cell-attached patches, providing a comparison to iberiotoxin, which is considered the gold standard BK channel blocker. This application aids in the development of new drugs and therapies targeting ion channels.
Used in Neural Stem Cell Transplantation Studies:
Penitrem A may be used to partially ablate Purkinje cells in the immature rat cerebellum, providing a model for neural stem cell transplantation studies. This application contributes to the advancement of regenerative medicine and the treatment of neurological disorders.
Chemical Properties:
Penitrem A is a solid mycotoxin with the chemical formula (12627-35-9). It is isolated from Penicillium species and forms colorless crystals when extracted from ethanol.

Biochem/physiol Actions

Penitrem A intoxication causes ataxia, polypnea, and sustained tremors and may lead to seizures and death. Penitrem A affects the central and peripheral nervous system. It impairs the GABAergic neurotransmission in the cerebellum.

Safety Profile

Poison by ingestion and intraperitoneal routes. An experimental teratogen. When heated to decomposition it emits very toxic fumes of Clí and NOx.

References

References/Citations:

Check Digit Verification of cas no

The CAS Registry Mumber 12627-35-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,2,6,2 and 7 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 12627-35:
(7*1)+(6*2)+(5*6)+(4*2)+(3*7)+(2*3)+(1*5)=89
89 % 10 = 9
So 12627-35-9 is a valid CAS Registry Number.
InChI:InChI=1/C37H44ClNO6/c1-15(2)28-27(40)31-37(45-31)23(43-28)9-10-33(6)34(7)18(8-11-35(33,37)41)29-25-24-21(39-30(25)34)14-20(38)17-12-16(3)19-13-22(32(4,5)44-29)36(19,42)26(17)24/h14,18-19,22-23,27-29,31,39-42H,1,3,8-13H2,2,4-7H3/t18-,19+,22+,23-,27-,28+,29-,31+,33+,34+,35-,36+,37-/m0/s1

12627-35-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name penitrem A

1.2 Other means of identification

Product number -
Other names Tremortin A

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:12627-35-9 SDS

12627-35-9Upstream product

12627-35-9Related news

Full length articleThe fungal neurotoxin PENITREM A (cas 12627-35-9) induces the production of reactive oxygen species in human neutrophils at submicromolar concentrations08/15/2019

Penitrem A is a fungal neurotoxin that recurrently causes intoxication in animals, and occasionally also in humans. We have previously reported that penitrem A induced the production of reactive oxygen species (ROS) in rat cerebellar granule cells, opening for a new mechanism of action for the n...detailed

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