12627-35-9 Usage
Description
Penitrem A is a tremorgenic mycotoxin, a toxic substance produced by certain fungi, specifically Penicillium species. It is a selective, irreversible blocker of the smooth muscle high conductance Ca2+-activated K+ (BK, KCa1.1) channel, which plays a significant role in vascular function and neuronal signaling. Penitrem A displays neurotoxicity in rats, causing convulsions and death in a dose-dependent manner. It forms colorless crystals when extracted from ethanol.
Uses
Used in Neurophysiological Research:
Penitrem A is used as a Ca2+-Activated K+ (BK) channel blocker to study its effect on BK current in bag cell neurons. This application helps researchers understand the role of BK channels in neuronal signaling and their potential involvement in various neurological conditions.
Used in Vascular Function Studies:
As an important tool for studying the role of BK channels in vascular function, Penitrem A is effective in cellular, tissue, and in vivo experiments. It helps researchers explore the mechanisms of blood vessel regulation and the potential therapeutic targets for cardiovascular diseases.
Used in Ion Channel Research:
Penitrem A is used to inhibit BK channels in inside-out and cell-attached patches, providing a comparison to iberiotoxin, which is considered the gold standard BK channel blocker. This application aids in the development of new drugs and therapies targeting ion channels.
Used in Neural Stem Cell Transplantation Studies:
Penitrem A may be used to partially ablate Purkinje cells in the immature rat cerebellum, providing a model for neural stem cell transplantation studies. This application contributes to the advancement of regenerative medicine and the treatment of neurological disorders.
Chemical Properties:
Penitrem A is a solid mycotoxin with the chemical formula (12627-35-9). It is isolated from Penicillium species and forms colorless crystals when extracted from ethanol.
Biochem/physiol Actions
Penitrem A intoxication causes ataxia, polypnea, and sustained tremors and may lead to seizures and death. Penitrem A affects the central and peripheral nervous system. It impairs the GABAergic neurotransmission in the cerebellum.
Safety Profile
Poison by ingestion and intraperitoneal routes. An experimental teratogen. When heated to decomposition it emits very toxic fumes of Clí and NOx.
References
References/Citations:
Check Digit Verification of cas no
The CAS Registry Mumber 12627-35-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,2,6,2 and 7 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 12627-35:
(7*1)+(6*2)+(5*6)+(4*2)+(3*7)+(2*3)+(1*5)=89
89 % 10 = 9
So 12627-35-9 is a valid CAS Registry Number.
InChI:InChI=1/C37H44ClNO6/c1-15(2)28-27(40)31-37(45-31)23(43-28)9-10-33(6)34(7)18(8-11-35(33,37)41)29-25-24-21(39-30(25)34)14-20(38)17-12-16(3)19-13-22(32(4,5)44-29)36(19,42)26(17)24/h14,18-19,22-23,27-29,31,39-42H,1,3,8-13H2,2,4-7H3/t18-,19+,22+,23-,27-,28+,29-,31+,33+,34+,35-,36+,37-/m0/s1
