1262758-96-2Relevant academic research and scientific papers
An efficient oxidative dearomatization-radical cyclization approach to symmetrically substituted bicyclic guttiferone natural products
McGrath, Nicholas A.,Binner, Joshua R.,Markopoulos, Georgios,Brichacek, Matthew,Njardarson, Jon T.
, p. 209 - 211 (2011/03/19)
Detailed in this communication is an efficient synthetic approach towards the guttiferone family of natural products. Oxidatively unraveling a para-quinone monoketal followed by consecutive 5-exo radical cyclizations provides the bicyclic core. An additional strength of this approach is a late stage asymmetric desymmetrization of an advanced symmetric intermediate.
