1262779-53-2Relevant academic research and scientific papers
Design, synthesis, and biological effect of (1-oxo-1,2,3,4-tetrahydro-β-carbolin-9-yl)-acetic acids as inhibitor of aldose reductase 2
Toyooka, Naoki,Takeda, Daisuke,Minoshima, Yuka,Kato, Atsushi,Adachi, Isao
experimental part, p. 1073 - 1080 (2009/12/26)
Design and synthesis of (1-oxo-l,2,3,4-tetrahydro-β-carbolin-9-yl)acetic acids (4a-e) have been described. The acids (4a-e) synthesized here showed good to moderate inhibitory effects (IC50 = 21.7 ~ 45.3 μM) for the aldose reductase 2 (ALR2).
