1262872-30-9Relevant academic research and scientific papers
Bio-inspired dual-selective BCL-2/c-MYC G-quadruplex binders: Design, synthesis, and anticancer activity of drug-like imidazo[2,1-i]purine derivatives
Pelliccia, Sveva,Amato, Jussara,Capasso, Domenica,Di Gaetano, Sonia,Massarotti, Alberto,Piccolo, Marialuisa,Irace, Carlo,Tron, Gian Cesare,Pagano, Bruno,Randazzo, Antonio,Novellino, Ettore,Giustiniano, Mariateresa
, p. 2035 - 2050 (2020)
In the search for new drug-like selective G-quadruplex binders, a bioinspired design focused on the use of nucleobases as synthons in a multicomponent reaction was herein proved to be viable and successful. Hence, a new class of multifunctionalized imidaz
Groebke-Blackburn-Bienaymé multicomponent reaction in scaffold-modification of adenine, guanine, and cytosine: Synthesis of aminoimidazole-condensed nucleobases
Guchhait, Sankar K.,Madaan, Chetna
experimental part, p. 56 - 58 (2011/02/26)
A multicomponent method for scaffold-modification of nucleobases (adenine, guanine, and cytosine) was developed. This modification approach, as an alternative to usual synthetic routes involving protection-deprotection or SNAr of halo (or leavi
