126301-11-9

Upstream product

• 66684-74-0 dimethyl (E)-cinnamylidenemalonate 
• 110269-68-6 tert-butyl ((1R,4R)-bornylideneamino)acetate 
• 37755-22-9 dimethyl 2-(3-phenylprop-2-en-1-ylidene)malonate 
• 104505-09-1 t-butyl (bornylideneamino)acetate 

Downstream Products

• 126301-15-3 2-tert-butyl methyl (2R,3R,4R)-3-<(E)-2-phenylvinyl>-5-oxopyrrolidine-2,4-dicarboxylate 
• 126301-15-3 (2R,3R,4R)-5-Oxo-3-((E)-styryl)-pyrrolidine-2,4-dicarboxylic acid 2-tert-butyl ester 4-methyl ester 

Relevant academic research and scientific papers

Highly Diasteroselective Michael-Addition of Lithiated Camphor Imines of Glycine Esters to α,β-Unsaturated Esters. Synthesis of Optically Pure 5-Oxo-2,4-pyrrolidinedicarboxylates of Unnatural Stereochemistry

The lithium enolates of camphor imines of glycine esters underwent highly diastereoselective Michael additions to the α,β-unsaturated esters.The tightly chelated structure of the Z,E enolates and the selective approach of the α,β-unsaturated esters to the

Absolutely Diastereoselective Asymmetric Michael Addition of the Camphor Imine of t-Butyl Aminoacetate with 2-Alkylidenemalonates

The lithium enolate generated from t-butyl (bornylideneamino)acetate and butyllithium in the presence of t-butyl alcohol undergoes highly diastereoselective asymmetric Michael addition with a variety of α,β-unsaturated esters to afford the anti derivatives of 3-substituted glutamates with 2R-configuration as major products.Use of 2-alkylidenemalonates as Michael acceptors leads to 100 percent diastereoselective Michael additions.