Highly Diasteroselective Michael-Addition of Lithiated Camphor Imines of Glycine Esters to α,β-Unsaturated Esters. Synthesis of Optically Pure 5-Oxo-2,4-pyrrolidinedicarboxylates of Unnatural Stereochemistry

Article abstract of DOI:10.1021/jo00008a052

The lithium enolates of camphor imines of glycine esters underwent highly diastereoselective Michael additions to the α,β-unsaturated esters.The tightly chelated structure of the Z,E enolates and the selective approach of the α,β-unsaturated esters to the