126301-16-4

Basic information

• Product Name: (S)-Methanesulphonic acid 2-Boc-aminopropyl ester
• Synonyms: (S)-Methanesulphonic acid 2-Boc-aminopropyl ester;(S)-2-(tert-butoxycarbonylaMino)propyl Methanesulfonate;(S)-Methanesulfonic acid 2-Boc-amino-propyl ester
• CAS NO: 126301-16-4
• Molecular Formula: C₉H₁₉NO₅S
• Molecular Weight: 253
• Mol File: 126301-16-4.mol

Chemical Properties

• Boiling Point: 397.918°C at 760 mmHg
• Flash Point: 194.454°C
• Appearance: /
• Density: 1.166g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.462
• CAS DataBase Reference: (S)-Methanesulphonic acid 2-Boc-aminopropyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-Methanesulphonic acid 2-Boc-aminopropyl ester(126301-16-4)
• EPA Substance Registry System: (S)-Methanesulphonic acid 2-Boc-aminopropyl ester(126301-16-4)

Safety Data

• Hazardous Substances Data: 126301-16-4(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
(S)-Methanesulphonic acid 2-Boc-aminopropyl ester is used as a reagent for the protection of amine groups in organic synthesis. The Boc group allows for the temporary shielding of the amine functionality, preventing unwanted side reactions and enabling selective reactions to occur at other sites on the molecule.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, (S)-Methanesulphonic acid 2-Boc-aminopropyl ester is utilized as a key intermediate in the synthesis of various drug molecules. Its ability to protect amine groups simplifies the synthesis process and allows for the introduction of complex functional groups, leading to the development of novel and effective therapeutic agents.
Used in Agrochemical Synthesis:
(S)-Methanesulphonic acid 2-Boc-aminopropyl ester is also employed in the agrochemical sector for the synthesis of pesticides, herbicides, and other crop protection agents. Its protective properties for amine groups enable the creation of more effective and targeted agrochemicals with reduced environmental impact.
Used in Fine Chemicals Synthesis:
(S)-Methanesulphonic acid 2-Boc-aminopropyl ester finds application in the synthesis of fine chemicals, such as specialty chemicals, fragrances, and flavorings. The versatility of (S)-Methanesulphonic acid 2-Boc-aminopropyl ester in protecting amine groups allows for the development of high-quality and complex fine chemicals with specific properties and applications.

InChI:InChI=1/C9H19NO5S/c1-7(6-14-16(5,12)13)10-8(11)15-9(2,3)4/h7H,6H2,1-5H3,(H,10,11)/t7-/m0/s1

Upstream product

• 79069-13-9 (S)-2-t-butoxycarbonylaminopropan-1-ol 
• 109208-68-6 Boc-Ala-O-COO-isoBu 
• 15761-38-3 L-N-Boc-Ala 
• 2749-11-3 (S)-Alaninol 
• 124-63-0 methanesulfonyl chloride 
• 28875-17-4 (S)-N-(tert-butoxycarbonyl)alanine methyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 3744-87-4 Boc-(R)-Ala 
• 129991-09-9 (R)-N-Boc-2-aminobutane 
• 79069-13-9 (R)-2-tertbutoxycarbonylamino-1-propanol 
• 91103-47-8 N-(tert-butoxycarbonyl)-D-alanine methyl ester 

Downstream Products

• 129319-91-1 (R)-(-)-N-(tert-Butoxycarbonyl)-2-methylaziridine 
• 100927-10-4 tert-butyl N-[(1R)-2-amino-1-methyl-ethyl]carbamate 
• 172695-22-6 (2-cyano-1(S)-methylethyl)carbamic acid, 1,1-dimethylethyl ester 
• 170367-78-9 [4-[[3-[[(1,1-dimethylethoxy)carbonyl]amino]butyl](phenylmethyl)amino]butyl]carbamic acid, 11-[[(1,1-dimethylethoxy)carbonyl]amino]-15,15-dimethyl-2,13-dioxo-14-oxa-3,4,12-triaza-11-hexadecen-1-yl ester (R) 
• 170367-82-5 [21-[[(1,1-dimethylethoxy)carbonyl]amino]-1,25,25-trimethyl-10,12,23-trioxo-4-(phenylmethyl)-24-oxa-4,9,13,20,22-pentaaza-21-hexacosen-1-yl]carbamic acid, 1,1-dimethylethyl ester (R) 
• 170367-76-7 2,2,6-trimethyl-4,15-dioxo-9-(phenylmethyl)-3,16-dioxa-5,9,14-triazaoxadecan-18-oic acid (R) 
• 252353-69-8 [3-[[4-(2,4-dioxo-3-oxazolidinyl)butyl](phynylmethyl)amino]-1-methylpropyl]carbamic acid, 1,1-dimethylethyl ester (R) 
• 170367-72-3 3-[(4-aminobutyl)(phenylmethyl)amino-1(R)-methylpropyl]carbamic acid, 1,1-dimethylethyl ester 
• 170367-71-2 3-[(3-cyanopropyl)(phenylmethyl)amino-1(R)-methylpropyl]carbamic acid, 1,1-dimethylethyl ester 
• 170367-70-1 [1(R)-methyl-3-[(phenylmethyl)amino]propyl]carbamic acid, 1,1-dimethylethyl ester 
• 170367-69-8 (3-amino-1(R)-methylpropyl)carbamic acid, 1,1-dimethylethyl ester 
• 170367-68-7 (2-cyano-1(R)-methylethyl)carbamic acid, 1,1-dimethylethyl ester 

Relevant articles and documents

Urea based foldamers

N,N′-linked oligoureas are a class of enantiopure, sequence-defined peptidomimetic oligomers without amino acids that form well-defined and predictable helical structures akin to the peptide α-helix. Oligourea-based foldamers combine a number of features—such as synthetic accessibility, sequence modularity, and folding fidelity—that bode well for their use in a range of applications from medicinal chemistry to catalysis. Moreover, it was recently recognized that this synthetic helical backbone can be combined with regular peptides to generate helically folded peptide-oligourea hybrids that display additional features in terms of helix mimicry and protein-surface recognition properties. Here we provide detailed protocols for the preparation of requested monomers and for the synthesis and purification of homo-oligoureas and peptide-oligourea hybrids.

Evaluation of 5-(Trifluoromethyl)-1,2,4-oxadiazole-Based Class IIa HDAC Inhibitors for Huntington's Disease

Using an iterative structure-activity relationship driven approach, we identified a CNS-penetrant 5-(trifluoromethyl)-1,2,4-oxadiazole (TFMO, 12) with a pharmacokinetic profile suitable for probing class IIa histone deacetylase (HDAC) inhibition in vivo.

HETEROCYCLIC COMPOUNDS

Provided herein are compounds of formula (I) which comprise a thiomorpholine 1,1-dioxide or 1-imino-thiomorpholine 1-oxide moiety, or pharmaceutically acceptable salts of any of the foregoing, pharmaceutical compositions that include a compound described herein (including salts of the compound) and methods of synthesizing the same. Also provided are methods of treating Hepatitis B viral (HBV) infections using a compound of formula (I), or pharmaceutically acceptable salts thereof.

PYRAZINE COMPOUNDS AND USES THEREOF

The present disclosure novel pyrazine compounds targeting adenosine receptors (especially A1 and A2, particularly A2a). The present disclosure also relates to pharmaceutical compositions comprising one or more of the compounds as an active ingredient, and use of the compounds in the treatment of adenosine receptor (AR) associated diseases, for example cancer such as NSCLC, RCC, prostate cancer, and breast cancer.

SULFUR-CONTAINING POLYCYCLIC-HYDROXYPYRIDONE CARBOXAMIDE ANALOG AGAINST HIV

The disclosure discloses a sulfur-containing polycyclic-hydroxypyridone carboxamide analog against HIV and an application thereof. The sulfur-containing polycyclic-hydroxypyridone carboxamide analog has a compound represented by the following formula (I)

TRICYCLIC 2-QUINOLINONES AS ANTIBACTERIALS

This invention is in the field of medicinal chemistry and relates to compounds, and pharmaceutical compositions thereof that are useful as antibacterial agents. The compounds are useful as inhibitors of bacterial gyrase activity and of bacterial infections, and have the structure of Formula (I): as further described herein. The invention further provides pharmaceutical compositions comprising a compound of Formula (I) and methods of using the compounds and compositions to treat bacterial infections.

MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS

Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

16-METHYL-OXACYCLOHEXADECAN-2-ONE AND 16-METHYL-AZACYCLOHEXADECAN-2-ONE DERIVATIVES AS ANTIMICROBIAL AGENTS

16-membered macrolide compounds inhibit growth of various microbial species and have utility in the treatment of systemic or topical microbial infections, including methicillin-resistant strains (Formula I).

PIPERIDINE DERIVATIVES AS INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7

The present invention concerns the identification of inhibitors of ubiquitin specific protease 7 (USP7), and methods of use thereof.

Identification of highly selective and potent orexin receptor 1 antagonists derived from a dual orexin receptor 1/2 antagonist based on the structural framework of pyrazoylethylbenzamide

The design, synthesis, and structure activity relationships of the novel class of pyrazolylethylbenzamide orexin receptor 1-selective antagonists are described. Further derivatization of the prototype dual orexin receptor 1/2 antagonist lead (1) by instal