1263045-16-4 Usage
Description
Mal-amido-PEG4-acid is a PEG linker containing a maleimide group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.
Check Digit Verification of cas no
The CAS Registry Mumber 1263045-16-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,6,3,0,4 and 5 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1263045-16:
(9*1)+(8*2)+(7*6)+(6*3)+(5*0)+(4*4)+(3*5)+(2*1)+(1*6)=124
124 % 10 = 4
So 1263045-16-4 is a valid CAS Registry Number.
1263045-16-4Relevant articles and documents
Antibody drug conjugate, intermediate, preparation method, pharmaceutical composition and uses thereof
-
Page/Page column 133; 134; 137; 138, (2019/11/11)
Disclosed are an antibody drug conjugate IB, which uses ether linkages for connection, and improves the water solubility, stability and cytotoxicity in vivo and in intro, and an intermediate, a pharmaceutical composition, and uses of the antibody drug conjugate. The antibody drug conjugate has simple synthetic steps and a high yield.
ANTI-CD22 ANTIBODY-DRUG CONJUGATES AND METHODS OF USING THEREOF
-
Paragraph 0273; 0281, (2016/05/09)
The present disclosure provides anti-CD22 antibody-drug conjugates comprising a hydrophilic self-immolative linker. The present disclosures further provide compositions and methods for treating cancers.
