1263197-08-5

Basic information

• Product Name: C₂₇H₃₄ClFN₄O₂
• Synonyms: C₂₇H₃₄ClFN₄O₂
• CAS NO: 1263197-08-5
• Molecular Weight: 501.044
• Mol File: 1263197-08-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₇H₃₄ClFN₄O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₇H₃₄ClFN₄O₂(1263197-08-5)
• EPA Substance Registry System: C₂₇H₃₄ClFN₄O₂(1263197-08-5)

Safety Data

• Hazardous Substances Data: 1263197-08-5(Hazardous Substances Data)

Upstream product

• 1168139-44-3 (1R)-1-(2-fluorophenyl)propan-1-amine hydrochloride 
• 1448902-08-6 tert-butyl (3R,5S)-3-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-5-{[(1R)-1-(2-fluorophenyl)propyl]carbamoyl}piperidine-1-carboxylate 
• 1263198-18-0 (3S,5R)-1-tert-butoxycarbonyl-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxylic acid 
• 1263198-12-4 1-tert-butyl 3-methyl (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-1,3-dicarboxylate 
• 1263198-15-7 methyl (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxylate 
• 1263198-04-4 methyl (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-1-(2-nitrophenyl)sulfonylpiperidine-3-carboxylate 
• 1263198-01-1 methyl (3S,5R)-5-{[2-(2-chloroanilino)-1,1-dimethylethyl]amino}-1-(2-nitrophenyl)sulfonylpiperidine-3-carboxylate 
• 1263197-96-1 methyl (3S,5R)-5-[(1,1-dimethyl-2-oxoethyl)amino]-1-(2-nitrophenyl)sulfonylpiperidine-3-carboxylate 
• 1448902-05-3 1-tert-Butyl 3-methyl (3S,5R)-5-[(1,1-dimethyl-2-oxoethyl)amino]piperidine-1,3-dicarboxylate 
• 1263197-89-2 1-tert-butyl 3-methyl (3S,5R)-5-aminopiperidine-1,3-dicarboxylate 
• 446-22-0 1-(2-fluorophenyl)propan-1-one 
• 1448902-46-2 (S_S)-N-[(1R)-1-(2-fluorophenyl)propyl]-2-methylpropane-2-sulfinamide 
• 1448902-04-2 1-tert-butyl 3-methyl (3S,5R)-5-(benzyloxycarbonylamino)piperidine-1,3-dicarboxylate 
• 534572-20-8 (3S,5R)-1-(tert-butoxycarbonyl)-3-(methoxycarbonyl)piperidine-5-carboxylic acid 

Relevant articles and documents

Synthesis and optimization of novel (3S,5R)-5-(2,2-dimethyl-5-oxo-4- phenylpiperazin-1-yl)piperidine-3-carboxamides as orally active renin inhibitors

We report synthesis and optimization of a series of (3S,5R)-5-(2,2- dimethyl-5-oxo-4-phenylpiperazin-1-yl)piperidine-3-carboxamides as renin inhibitors. Chemical modification of P1, P2 and P 3 portions led to a promising 3