446-22-0

Basic information

• Product Name: 2-Fluoropropiophenone
• Synonyms: 1-(2-FLUOROPHENYL)PROPAN-1-ONE;2'-FLUOROPROPIOPHENONE;2-FLUOROPROPIOPHENONE;ETHYL 2-FLUOROPHENYL KETONE;2-Fluoropropiophendne;2'-FLUOROPROPIOPHENONE 98%;2-Fluoropropiophenone99%;o-Fluoropropiophenone
• CAS NO: 446-22-0
• Molecular Formula: C₉H₉FO
• Molecular Weight: 152.17
• EINECS: 244-220-7
• Product Categories: Aromatic Propiophenones (substituted);Aromatics
• Mol File: 446-22-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 95-99 °C19 mm Hg(lit.)
• Flash Point: 175 °F
• Appearance: Pale yellow oil
• Density: 1.102 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.5043(lit.)
• Storage Temp.: -20?C Freezer
• Solubility: Chloroform, Methanol
• Water Solubility: Soluble in chloroform, methanol. Not miscible in water.
• BRN: 3235723
• CAS DataBase Reference: 2-Fluoropropiophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoropropiophenone(446-22-0)
• EPA Substance Registry System: 2-Fluoropropiophenone(446-22-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 446-22-0(Hazardous Substances Data)

Usage

Chemical Properties

Pale Yellow Oil

Uses

2-Fluoropropiophenone (cas# 446-22-0) is a compound useful in organic synthesis.

Upstream product

• 394-47-8 2-fluorobenzonitrile 
• 133745-75-2 N-fluorobis(benzenesulfon)imide 
• 93-55-0 1-phenyl-propan-1-one 
• 4111-54-0 lithium diisopropyl amide 
• 58824-51-4 1-(2-fluorophenyl)-2-propen-1-ol 
• 446-52-6 2-Fluorobenzaldehyde 
• 54542-07-3 1-phenyl-propan-1-one-O-methyl-oxime 
• 925-90-6 ethylmagnesium bromide 
• 156022-15-0 1-(2-fluorophenyl)-1-propanol 
• 56314-65-9 1-allyl-2-fluorobenzene 
• 1072-85-1 o-fluorobromobenzene 

Downstream Products

• 394-35-4 methyl 2-fluorobenzoate 
• 1259438-69-1 4,6-dichloro-2-(2-fluorophenyl)-3-methylquinoline 
• 27508-24-3 3-ethylbenzo[b]thiophene-2-carboxylic acid 
• 1259513-43-3 4-(3,3-dimethyl-6-(4-morpholinyl)-2,3-dihydro-1H-indol-1-yl)-2-(2-fluorophenyl)-3-methylquinoline 
• 1259438-73-7 4-chloro-2-(2-fluorophenyl)-3-methylquinoline 
• 178625-01-9 C₁₅H₁₀FNO₃ 

Relevant articles and documents

Cobalt-Catalyzed Migrational Isomerization of Styrenes

An efficient cobalt-catalyzed migrational isomerization of styrenes was developed using the thiazoline iminopyridine (TIP) ligand. This reaction is operationally simple and atom-economical using readily available starting materials to access trisubstituted alkenes. Even when using a 0.1 mol % catalyst loading, the reaction could be conducted in neat and completed in 1 h with excellent conversion and high E stereoselectivity.

Direct conversion of allyl arenes to aryl ethylketones via a TBHP-mediated palladium-catalyzed tandem isomerization-Wacker oxidation of terminal alkenes

A TBHP-mediated palladium-catalyzed tandem isomerization-Wacker oxidation of terminal alkenes was developed. This methodology provides a new efficient and simple route for conversion of a range of allyl arenes directly into aryl ethylketones in good yields with high chemoselectivity.

A facile synthesis of α-fluoro ketones catalyzed by [Cp*IrCl2]2

Allylic alcohols are isomerized into enolates (enols) by [Cp*IrCl2]2. The enolates react with Selectfluor present in the reaction media. This method produces α-fluoro ketones as single constitutional isomers in high yields. Georg Thieme Verlag Stuttgart. New York.