1263273-14-8 Usage
Description
(1SR,2SR)-2-((3,5-dichlorophenyl)carbamoyl)cyclohexanecarboxylic acid is a carboxylic acid derivative featuring a cyclohexane ring, a carbamoyl group, and two chlorine atoms on the phenyl ring. This chemical compound possesses potential pharmacological properties and is currently under investigation for its anti-inflammatory and analgesic effects.
Uses
Used in Pharmaceutical Industry:
(1SR,2SR)-2-((3,5-dichlorophenyl)carbamoyl)cyclohexanecarboxylic acid is used as a potential therapeutic agent for the treatment of pain and inflammation-related conditions. Its anti-inflammatory and analgesic effects make it a candidate for further research and development in the pharmaceutical field.
The precise mechanisms of action and potential therapeutic applications of this compound are still being studied, with the aim of understanding its full potential as a valuable component in the development of new pharmaceutical compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 1263273-14-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,6,3,2,7 and 3 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1263273-14:
(9*1)+(8*2)+(7*6)+(6*3)+(5*2)+(4*7)+(3*3)+(2*1)+(1*4)=138
138 % 10 = 8
So 1263273-14-8 is a valid CAS Registry Number.
1263273-14-8Relevant articles and documents
Exploring the active conformation of cyclohexane carboxylate positive allosteric modulators of the type 4 metabotropic glutamate receptor
Rovira, Xavier,Harrak, Youssef,Trapero, Ana,Gonzlez-Bulnes, Patricia,Malhaire, Fanny,Pin, Jean-Philippe,Goudet, Cyril,Giraldo, Jesffls,Llebaria, Amadeu
, p. 2685 - 2698 (2014)
The active conformation of a family of metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulators (PAMs) with the cyclohexane 1,2-dicarboxylic scaffold present in cis-2-(3,5-dichlorophenylcarbamoyl)cyclohexanecarboxylic acid (VU0155041) was investigated by testing structurally similar six-membered ring compounds that have a locked conformation. The norbornane and cyclohexane molecules designed as mGlu4 conformational probes and the enantiomers of the trans diastereomer were computationally characterized and tested in mGlu4 pharmacological assays. The results support a VU0155041 active conformation, with the chair cyclohexane having the aromatic amide substituent in an axial position and the carboxylate in an equatorial position. Moreover, the receptor displays enantiomeric discrimination of the chiral PAMs. The constructed pharmacophore characterized a highly constrained mGlu4 allosteric binding site, thus providing a step forward in structure-based drug design for mGlu4 PAMs.
