1263277-06-0

Upstream product

• 201849-14-1 2-bromo-6-chloro-4-fluorophenylamine 
• 61272-77-3 2-cyano-4-fluoroaniline 

Downstream Products

• 1378040-49-3 2-{[1-(4-azido-5-fluoropyridin-3-yl)-meth-(E)-ylidene]-amino}-3-chloro-5-fluorobenzonitrile 
• 1378040-50-6 3-chloro-5-fluoro-2-(7-fluoropyrazolo[4,3-c]pyridin-2-yl)-benzonitrile 
• 1378040-52-8 3-chloro-2-(4-chloro-7-fluoropyrazolo[4,3-c]pyridin-2-yl)-5-fluorobenzonitrile 
• 1378040-51-7 3-chloro-5-fluoro-2-(7-fluoro-5-oxypyrazolo[4,3-c]pyridin-2-yl)-benzonitrile 
• 1378038-58-4 3-chloro-5-fluoro-2-[7-fluoro-4-(6-methylpyrimidin-4-ylamino)-pyrazolo[4,3-c]pyridin-2-yl]-benzonitrile 
• 1378040-53-9 2-(4-bromo-7-fluoropyrazolo[4,3-c]pyridin-2-yl)-3-chloro-5-fluorobenzonitrile 
• 1378040-54-0 {6-[2-(2-chloro-6-cyano-4-fluorophenyl)-7-fluoro-2H-pyrazolo[4,3-c]pyridin-4-ylamino]-2-methylpyrimidin-4-yl}bis-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

NOVEL NAPHTHYRIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ARRHYTHMIA

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; Wherein R1, R3-R6, X2 and X3 are as defined herein, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

PYRAZOLOPYRIDINES AND PYRAZOLOPYRIDINES AND THEIR USE AS TYK2 INHIBITORS

The invention provides compounds of Formula (I), stereoisomers or pharmaceutically acceptable salts thereof, wherein A, X, R1, R2, R4 and R5 are defined herein, a pharmaceutical composition that includes a compound of Formula (I) and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of using the compound or composition in therapy, as TYK2 Kinase inhibitors.